Senior Scientist, Biochemistry and Biophysics

Job Description

Our Company's Research Laboratories in South San Francisco is seeking a lab based Senior Scientist with experience in biochemical/biophysical assays and lead discovery support to join our Quantitative Biosciences (Pharmacology) department. The successful candidate will be responsible for the design, execution, and interpretation of binding and functional assays as well as mechanistic experimentation to advance early drug discovery projects across various modalities. The candidate will work closely with a team of multidisciplinary scientists to enable strategies for assay development, screening, and mechanism of action studies to advance a diverse portfolio of therapies for cardiometabolic disorders and oncology. We value transparent communication, creative thinking, teamwork, and rigorous scientific exploration. If you are a highly motivated individual and team player with a strong desire to impact drug discovery across multiple therapeutic areas, we invite you to consider joining our team.

Key Responsibilities:

• Develop and execute radioligand binding assays to characterize biomolecular interactions (equilibrium and kinetic) for lead discovery and optimization

• Support a wide range of biochemical and biophysical assays for screening and mechanistic studies using diverse experimental methodologies

• Ensure high-quality data generation, analysis, and timely report to project teams

• Leverage lab automation to improve assay operation, quality, and overall productivity

• Properly document experimental design, findings, and assay protocols; comply with all laboratory training and safety requirements

• Collaborate with colleagues within Quantitative Biosciences and on multi-disciplinary project teams to provide scientific/technical contributions and deliver on project goals

• Drive scientific and technical innovations to develop and enhance functional capabilities

Qualifications:

Education:

• Bachelor's or Master's (with 8+ years) or Ph.D. (with 2+ years) in Biochemistry, Biophysics or a related field with relevant experience in an academic or industry setting

Required Experience and Skills:

• Prior experience developing equilibrium and kinetic radioligand binding assays (e.g. 125I, 3H, 35S, 14C) in relevant formats (purified protein, cells and/or membranes)

• Demonstrated proficiency in a wide range of biochemical and biophysical assay methods and techniques (e.g. enzymatic and thermal shift assays using various detection technologies, SPR and other biosensors, mass spectrometry, etc.)

• Hands-on experience with liquid handling instruments (Apricot, Dragonfly, Bravo, Echo, etc.) for assay operation, as well as automated data processing and visualization software tools

• Strong work ethic and commitment to lab-based experimentation, as well as proven ability to independently design/execute experimental tasks and deliver results under tight timelines

• Excellent verbal, written, and interpersonal communication skills with a track-record of working effectively with diverse stakeholders in a cross-functional matrix team environment

Preferred Experience and Skills:

• Broad knowledge of G-protein coupled receptor (GPCR) pharmacology

• Tissue culture skills including cell plating, harvesting, and membrane preparation

• Protein biochemistry expertise (gene cloning, transfection, expression & purification)

• Prior experience as functional area representative in matrixed drug discovery project teams

• Prior experience with multiple therapeutic modalities (small molecule, peptide, antibody, antibody drug conjugate, etc.)

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