Associate Scientist - Process Development

We are seeking a highly motivated Principal Engineer to join the Downstream Process Development team. The successful candidate will lead development and optimization of downstream purification processes supporting viral vector programs from research through preclinical development. 

The ideal candidate will possess deep technical expertise in downstream purification technologies including ultracentrifugation, chromatography, and tangential flow filtration (TFF), with demonstrated experience driving process development strategies, platform development initiatives, technology implementation, and multi-functional collaboration. 

This role requires strong scientific leadership, hands-on technical capability, and the ability to independently lead complex purification development activities in a fast-paced environment. 

Key Responsibilities 

• Lead development, optimization, and scale-up of downstream purification workflows for viral vectors.  
• Design and implement purification strategieusingng Iodixanol and CsCl density gradient ultracentrifugation, affinity chromatography, ion-exchange chromatography (AEX/CEX), membrane chromatography, and polishing operations.  
• Lead AKTA-based chromatography workflow development and process intensification initiatives.  
• Develop scalable downstream platform approaches to support rapid material generation and process consistency across programs.  
• Independently design experiments, analyze data, interpret results, and present technical conclusions to multi-functional teams and leadership.  
• Drive troubleshooting, process characterization, and process robustness studies.  
• Collaborate closely with upstream, analytical, manufacturing, and external partners to support program deliverables and timelines.  
• Support technology transfer, process documentation, and development reports.  
• Lead development and optimization of TFF/UFDF workflows for concentration, buffer exchange, formulation, and process scalability.  
• Mentor junior scientists/engineers and provide technical guidance across purification activities.  
• Contribute to implementation of new purification technologies, automation tools, and continuous process improvements.  
• Ensure compliance with safety, documentation, and quality standards. 

Basic Qualifications 

• Master’s degree in biology, biochemistry, chemical engineering, biotechnology or related field
• 8+ years of relevant downstream process development experience in industry 

Additional Skills/Preferences: 

• CsCl and iodixanol ultracentrifugation  
• Affinity chromatography  
• Ion-exchange chromatography  
• TFF/UFDF operations including concentration, diafiltration, and formulation development  
• AKTA systems and Unicorn software  
• Strong understanding of process scale-up, platform development, and purification process characterization.  
• Experience analyzing purification performance and product quality attributes using relevant analytical methods. 
• Experience in AAV downstream process development and capsid enrichment workflows.  
• Experience with automated chromatography systems and process intensification strategies.  
• Experience supporting technology transfer and manufacturing readiness activities.  
• Familiarity with GMP development environments and regulatory expectations.