Senior Scientist, In Vivo Pharmacology, Oncology R&D

Senior Scientist, In Vivo Pharmacology, Oncology R&D, Gaithersburg, MD 

About this Opportunity 

Are you ready to make a difference in the world of Oncology? We are seeking a pharmacology Senior Scientist within the Oncology Targeted Delivery (OTD) group to serve as an in vivo lead supporting both preclinical and clinical programs. This role will work with colleagues to generate robust datasets directly impacting oncology ADC drug discovery and pipeline development.  

Key Duties and Responsibilities 

Working within the Early Oncology In Vivo Pharmacology Team, you will design, run and analyze in vivo experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will be expected to collaborate with cross-functional teams including representatives from biosciences, translational medicine, clinical, drug metabolism, pharmacokinetics, and safety to help understand the translatability of in vivo research to the clinic. You will work collaboratively with project leaders to ensure the timely generation, and dissemination of critical program data, and contribute to scientific publication goals. As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology, pharmacology and cancer modeling and have a genuine passion for this field of research. 

Essential Skills/Experience: 

• A PhD with at least two years or a BS/MS with at least five years of relevant research experience in biology, pharmacology, or a related scientific discipline is required. 

• Significant hands-on experience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic and orthotopic mouse models. 

• Experience executing in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies. 

• Adept at various routes of dosing administration, such as intravenous (IV), intraperitoneal (IP), and oral gavage (PO). 

• Ability to work independently, critically analyze and report data, and interpret experimental findings within the broader landscape of drug discovery. 

• Experience in preparing pharmacology project packages for internal milestone transitions and IND filings which exemplify a clear communication style. 

• In-depth knowledge of ADCs and oncology disease area biology (solid tumors). 

• Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca. 

• Highly developed problem solving and risk management skills, and attention to detail. 

• Strong interpersonal, collaborative and team building skills. 

About AstraZeneca 

At AstraZeneca, we are on a mission to eliminate cancer as a cause of death. We are a science-based, leading and decisive Oncology enterprise united in our vision. With one of th