Postdoctoral Fellow-MSH-30025-251

Research Focus

Our research aims to uncover the molecular mechanisms that govern cancer cell behavior by focusing on:

• Functional heterogeneity within tumors

• Phenotypic plasticity during tumor evolution and therapy response

• Cellular competence in tumor initiation, adaptation, and drug resistance

Rather than simply cataloging cellular states, we seek to identify the mechanisms that establish, maintain, and

regulate them. We combine genetic barcoding-based lineage tracing, functional genomics, organoid and

mouse models, CRISPR perturbations, and single-cell multiomics to track cancer evolution at clonal resolution

and uncover causal regulators of cancer cell identity and behavior.

The laboratory includes both experimental and computational researchers, fostering a collaborative and

interdisciplinary approach to studying cancer evolution and cell-state dynamics.

Current Research Areas

• Cellular competence and tumor evolution

• Phenotypic plasticity, memory, and adaptation

• Developmental programs and cancer cell states

Responsibilities

• Design and execute independent research projects.

• Perform experiments using organoid, cell culture, and mouse models.

• Conduct genetic barcoding, lineage tracing, and functional genomics studies.

• Contribute to manuscripts, grant applications, and mentoring activities.

Qualifications

Required

• Ph.D. in Cancer Biology, Molecular Biology, Genetics, Epigenetics, Stem Cell Biology, or a related field.

• Strong publication record or evidence of research productivity.

• Ability to work independently and collaboratively.

• Experience with molecular biology and mammalian cell culture.

Preferred

Experience in one or more of the following:

• Organoids or mouse models

• Genetic barcoding, clonal tracking, and lineage tracing

• Single-cell genomics and multiomics

• ATAC-seq, RNA-seq, CUT&Tag, or CUT&RUN

• CRISPR technologies

What We Offer

Join an NIH-funded laboratory and help shape an ambitious research program at the intersection of cancer

biology, epigenetics, stem cell biology, and genomics. Trainees will receive close mentorship, access to stateof-

the-art technologies, and strong support for career development and scientific independence.

Application Instructions

Please submit: Cover letter, CV and contact information for three references to slim.mzoughi@mssm.edu

Subject line: "Postdoctoral Fellow / Assistant Scientist Application – Mzoughi Lab"

Shortlisted candidates will be contacted for an interview.

Mount Sinai is an equal opportunity employer, and we encourage applications from individuals of all

backgrounds. We value diversity and inclusion in our research community.

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 824 - Oncological Sciences - ISM, Icahn School of Medicine

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and