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RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC).  Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

The laboratory-based role offers an opportunity to help advance novel Radiopharmaceutical therapies from laboratory into clinical testing. The candidate is responsible for developing and running surface plasmon resonance (SPR) assays for compound screening to support various pipeline projects. The ideal candidate will be a critical thinker and a technical problem solver who enjoys working in interdisciplinary drug discovery teams. The role requires an ability and willingness to work with radioactive isotopes.

*This is an onsite position located at Rayzebio's San Diego, CA office

Key Responsibilities:

• Develop and optimize SPR and biosensor-based assays for the evaluation of biomolecular interactions, particularly in the context of oncology targets to support the screening, characterization, and lead-identification of novel RPT agents.

• Conduct routine screening experiments using SPR and biosensor platforms to generate high-quality data for project teams.

• Operate and maintain SPR and biosensor instruments, ensuring optimal performance and troubleshooting technical issues as needed.

• Generate, organize, and maintain meticulous records on all conducted experiments. Independently analyze and interpret data and present experimental plans and results at project team meetings, group meetings, and company meetings.

• Actively contribute to the experimental design and planning efforts to help achieve project goals under tight timelines.

• Work with radioactivity in various assays in strict adherence to the radiation safety protocols.

• Work under the guidance of project team leaders to support the overall biology screening and evaluation plan, work closely with chemists, DMPK, imaging and in vivo teams to ensure implementation of screening funnel and appropriate prioritization of experiments.

• Collaborate with colleagues in other functional areas including translational research and chemistry.

• Assist in laboratory operation management duties.

Education and Experience:

• BS with 4+ years of experience or MS 2+ years of experience within Biology, Biochemistry, Molecular Biology, or a related discipline with hands on laboratory experience.

• Proven experience in SPR and biosensor assay development and operation, ideally within the oncology field.

• Hands-on expertise with SPR instruments (e.g., Biacore 8k, ProteOn) and biosensor technologies (e.g., BLI, SPRi).

• Prior experience of working on drug discovery projects in an industrial or an academic setting is preferred.