Technical Program Manager (Sr. Mgr or Assoc. Director)

About Us: 

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions. 

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location. Reporting directly or operationally into the VP, Information Technology, the role supports the broader coordination of efforts across teams to ensure impactful contributions to AI integration 

 

Position Summary:

Structure Therapeutics is seeking a Sr. Technical Project / Program Manager to lead a portfolio of high-impact IT initiatives spanning R&D, G&A, and AI/Infrastructure platforms. This role is critical to enabling scientific innovation and enterprise scale by delivering complex, cross-functional programs with precision, transparency, and speed.
Operating at the level expected in leading biotech organizations, this individual will drive end-to-end program execution, establish strong delivery governance, and ensure alignment between scientific, corporate, and technology priorities. This role requires a balance of deep program management discipline, technical fluency, and AI-forward thinking, with a strong focus on execution excellence and executive communication.
 

Job Responsibilities:

 

Program & Project Leadership

• Lead end-to-end delivery of complex IT programs across:
  • R&D systems (Clinical, Discovery, Preclinical)
  • G&A systems (Finance, HR, Legal, collaboration tools)
  • AI/ML and infrastructure platforms
• Drive program planning, execution, and delivery across the full Software Development Lifecycle (SDLC)
• Manage multiple concurrent initiatives with clear prioritization, resource alignment, and delivery accountability
• Ensure delivery within scope, timeline, budget, and quality expectations
  

Delivery Methodology & Execution Excellence

• Apply strong expertise in Agile, Waterfall, and hybrid delivery models, selecting the right approach based on program needs
• Establish structured project plans, milestones, and dependencies across technical and business teams
• Proactively manage risks, issues, and interdependencies with a solutions-oriented mindset
• Drive continuous improvement in delivery frameworks, tools, and operational rigor

Cross-Functional IT & Business Partnership

• Work closely with IT functions including Security, Infrastructure, Applications, Data/AI, and Enterprise Systems
• Partner with business stakeholders across R&D and G&A to define requirements, align priorities, and drive adoption
• Serve as the connective layer between engineering, architecture, and business teams to ensure cohesive execution
• Coordinate internal teams and external vendors/partners

Executive Reporting & Governance

• Own program governance, including steering committees, status reporting, and executive updates
• Deliver clear, concise, and data-driven reporting on program health, risks, and outcomes
• Translate complex technical initiatives into business-relevant insights for senior leadership
• Drive decision-making through structured communication and escalation management

AI & Digital Enablement

• Lead and support initiatives involving AI/ML platforms, data infrastructure, and automation
• Demonstrate AI literacy, leveraging modern AI tools to improve productivity and delivery outcomes
• Partner with data and engineering teams to enable scalable, production-ready AI solutions

PMO & Operational Leadership

• Contribute to building and scaling IT PMO capabilities