Principal Scientist, Oncology Discovery Biology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients.  Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies.  With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome.  We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets.   We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.  We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area

Position Summary:

We are seeking an innovative and independent immunologist and leader to shape and advance our portfolio of pioneering T cell engager therapeutics to treat cancers. The successful candidate will join the Discovery Biology Team within the Oncology Thematic Research Center at Bristol Myers Squibb in Seattle, WA. The qualified candidate will provide expertise in immunology and program leadership and will join a multidisciplinary, groundbreaking team driving projects from discovery through IND. Using their knowledge in T cell immunology, the candidate will have the opportunity to identify and validate novel targets, design and validate novel assay systems to enable next-generation engagers for cancer and drive projects through the discovery pipeline.  This scientist will work in a highly collaborative, dynamic, fast-paced environment involving multiple teams across the company.

Position Responsibilities:

In the role as a Principal Scientist within Discovery Biology, the ideal candidate will:

• Lead highly matrixed, cross functional, immune engager discovery teams from target concept to IND and lead and participate in activities of a biology team supporting in vitro and ex vivo experimentation.

• Apply knowledge of T cell biology to develop next-generation T cell engagers with improved efficacy and safety profiles.  

• Apply extensive technical knowledge to leverage current and new techniques to design and implement studies critical to drive hypothesis-driven research.

• Design and execute on cutting edge in vitro and ex vivo experiments.

• Collaborate with functional area leads (e.g. pharmacology, DMPK, informatics and predictive science) to drive programs forward, including helping to define program priorities and risks.

• Present key strategic concepts and project progression at an appropriate level to a range of audiences including full team project meetings and corporate governance.

• Utilize excellent communication and interpersonal skills to drive effective collaboration and align with key stakeholders.

Experience =

Basic Qualifications:

• Bachelor’s Degree

  • 8+ years of academic and / or industry experience

Or

• Master’s Degree

  • 6+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences 

  • 4+ years of academic and / or industry exp