Senior Scientist Crystallization

Job title: Senior Scientist Crystallization

Location: Cambridge, MA

About the Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

We are looking for a highly motivated individual with a mindset to implement changes. She/He will be recognized as technical expert in the field of crystallization and solid-state chemistry. The successful candidate will work in a cutting-edge scientific global crystallization department in Sanofi’s R&D CMC Synthetic organization.  The job is in Cambridge MA, but close collaboration with colleagues in France is required.  Crystallization Scientists work cross functionally to select active pharmaceutical ingredients (API) solid forms for development and deliver robust commercial API crystallization processes.  Process development may be directed to either batch or continuous processes.  Collaborative work with Chemists and Engineers on complex drug substance intermediate crystallizations will also be required.  Work starts at candidate selection and continues to commercial launch.  We strongly believe that innovation in process development, data science and modelling will be key drivers to transform Pharma process development. 

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities: 

• Work with internal partners in Drug Product development, Biopharmaceutics and Analytical to select the API physical form for new NCEs.  This includes assessment of the manufacturability (API solid form space complexity, physical properties, scalability, stability) 

• Development of processes to consistently produce API with the required quality attributes using both batch and continuous platforms.  Expectations include; 

• Team Interactions – Integrate closely with project team members such as Chemists, Analysts, Formulators and Engineers/Modelers to develop API processes that are closely coordinated with API route selection and Drug Product development.   

• Digital Development – Apply AI/Modeling to transform development from traditional data driven statistical approaches to more efficient and effective Digital Development. 

• Domain knowledge - Use a strong background in Crystallization Engineering and/or Solid-State Chemistry to understand and apply strategies to control API physiochemical properties such as particle size distribution, impurities concentration and crystal form. 

• Experimentation – Apply strong lab skills to deliver well designed efficient experimental plans required for process development across a wide range of crystallization, i