Research Associate, Neuromuscular Research

Company Overview:

Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. For more information, please visit https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. 

Role Summary: 

The Research Associate in the Neuromuscular Research Group will be responsible for conducting preclinical research to develop novel therapies with the goal of providing functional improvement in people living with neuromuscular disorders. The role supports the execution of multiple research projects and will collaborate closely within the Neuromuscular Research team and cross-functionally. This role requires a results-driven mindset, the ability to thrive in a fast-paced environment, and a strong desire for personal and professional growth beyond comfort zones.

This role is based in Waltham, MA without the possibility of being fully remote. 
 
Primary Responsibilities Include: 

• Execute in vitro and in vivo studies to support PK/PD and mechanism-of-action analysis of therapeutic candidates, including but not limited to: 

• Executing molecular biology assays to assess gene and protein expression  

• Performing routine cell culture and cell-based assays 

• Performing in vivo pharmacology procedures, including but not limited to routine rodent handling, blood and tissue collection, necropsy and processing 

• Maintain accurate and detailed records of experiments and results in electronic notebooks  

• Analyze and organize data diligently and proactively communicate experiment progress to team members in a timely manner 

• Actively contribute to experimental design, assay development and optimization, and project discussions 

 

Education and Skills Requirements: 

• BS/MS or equivalent in a biology, neuroscience, or relevant discipline  

• 1-3 years of direct biotech/biopharma or academic experience 

• Proficiency with molecular and cellular biology techniques including: 

• Handling biological samples, especially cell or tissue samples  

• Sterile techniques, routine mammalian cell culture and cell-based assays 

• Protein isolation from biological samples and detection by methods such as Western blots and ELISA 

• Nucleic acid extraction and gene expression analysis  

• Experience in working with rodent models, including but not limited to: 

• Basic rodent handling  

• Blood and tissue collection and necropsy 

• Exceptional attention to details and a strong track record of experimental rigor  

• Excellent organizational skills and diligent with record keeping 

• Highly motivated teamplayer with excellent communicational skills  

• Experienced in the use of software applications such as Prism, Image J, Excel, and PowerPoint 

 

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The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of