Senior Scientist, Systems Biology Toxicologist

Job Description

Position Description:

Senior Scientist, Systems Biology Toxicologist

The Non-Clinical Drug Safety (NDS) organization of our company's Research Laboratories is currently seeking a Senior Genomics Scientist within Investigative Toxicology at the West Point, PA site. 

The scientist will drive the development and application of cutting-edge genetics and genomics assays towards the identification and mechanistic de-risking of program liabilities. 

Responsibilities include:

• Spearheading the development and automation of laboratory protocols for advanced genetics/genomics/epigenetics capabilities (eg: spatial RNA-seq, DRUG-seq, etc)

• Implementing data processing and analytical pipelines for developed capabilities, as well as analyzing and interpreting associated biological findings

• Applying developed capabilities for program risk assessment and mechanistic investigations into toxicologic findings

• Working closely with laboratory scientists and analysts across toxicology disciplines to integrate ‘omics capabilities into multi-modal assessments and prediction algorithms (eg: combining spatial ‘omics with digital histopathology)

• Spearheading both internal and peer-reviewed publications and presentations

Position Qualifications:

Education Minimum Requirement:

• Ph.D. in toxicology, genetics/genomics, bioinformatics or related discipline

• Master's (with 4+ years) or

• Bachelor's (with 8+ years) in toxicology, genetics/genomics, bioinformatics or related discipline and relevant industry experience

  Required Experience and Skills:

  • Prior laboratory experience with advanced next generation sequencing (NGS) applications (eg: scRNA-seq, spatial sequencing, etc)

  • Prior experience with processing and analysis of diverse NGS datasets via command line interface and mathematical programing software (R/Python)

  • Strong understanding of mammalian biology, genetics, genomics and epigenetics

  • Passion for development of novel technologies and application to drug development

  • Strong communication, collaboration, and leadership skills including ability to distill and communicate complex genomics concepts and results to scientists from diverse disciplines

  Preferred Experience and Skills:

  • Relevant industry experience, especially in toxicology

  • Experience with biochemical assay automation and robotics

  • Experience with high performance and cloud-based computing

  NOTICE FOR INTERNAL APPLICANTS

  In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

   

  If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as