Senior Lead, Preclinical Development

Job Description Summary

-Conducts exploratory research to produce new knowledge and potential products; conceives, organizes, promotes, and executes ideas and plans to increase chemistry'srole in and contribution to the discovery and chemical approaches to meet exploratory objectives in product discovery. Develops research proposals to provide atechnically and economically sound basis for developing and evaluating new or improved products, synthetic methods, processes, and analytical and physical testingtechniques. Recommends utilization of the results or changes in the scope of work or termination of projects. -Principal Scientist II:Participates in and/or leads multidisciplinary teams together with scientists from other units in Novartis; may work with external partners. Leads a lab and/or a project or technology area, integrating independent experimental work to drive achievement of goals with increasing efficiency. Builds increasingly broad scientific/technical/development toolkit for self and team, or deepens own technical/scientific specialty and enables Division community in own areas of expertise. -Principal Scientist I:Influences and drives projects using broad, up‐to‐date knowledge of a scientific/technical/development discipline or area of specialization,with developing people leadership skills or deep expertise in one or more scientific/technical areas. Uses broad understanding of the project and drug discovery pipeline and leads own team through collaboration and curiosity, or connects to matrix community surrounding specific area of deep expertise to generate and answer key scientific/technical questions.

 

Job Description

 

Internal Job Title: Senior Expert: Science and Technology (Level 4/GJFA 5) 

Position Location: Cambridge, MA, onsite 

 

 

Job Description:  

  

Technical Research & Development (TRD) is seeking a highly motivated individual to join the discovery pharmaceutics function, Chemical and Pharmaceutical Profiling (CPP), and contribute to the development of discovery compounds. This successful candidate will join an energizing and collaborative research environment working as part of cross functional drug discovery teams in providing a developability assessment of new chemical entities. 

 

The ideal candidate must be capable of working independently to support projects through the preclinical stages by being a core team member of the research teams and providing a developability assessment of small molecules to expedite them into preclinical PK, PD and tox studies via formulation. Additionally, they will recommend physical form and clinical formulation principles based on biopharmaceutical properties to ensure smooth knowledge transfer to early development colleagues. As such, strong competency in physical pharmacy, preclinical formulation development and biopharmaceutics is required to efficiently function in this role and in understanding the physicochemical properties of new chemical entities and implementing formulation strategies to maximize the exposure in preclinical in vivo studies.  

 

The candidate must demonstrate and foster strong team spirit and promote knowledge exchange within and between teams. Furthermore, the candidate should be able to proactively manage the interactions of project related activities between CPP and other departments such as research and pharmaceutical development. The candidate must ensure alignment with other departments and functions and 3rd parties, as appropriate. To accomplish this, the role requires timely communication of overall project information to the appropriate management level via oral and written communication and ensuring that the project team obj