Post-Doctoral Research Fellow - Hatch Lab

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

 

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

 

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

 

Fred Hutch and the Hatch lab are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We encourage individuals with diverse backgrounds to apply. Fred Hutch has more than 200 postdoctoral fellows working in labs across five research divisions. We provide postdocs the opportunity to work on the cutting edge of biomedical research in a supportive, collaborative environment with faculty and staff who are dedicated to helping trainees achieve their career goals. In addition, the Student/Postdoc Advisory Committee and the Office of Scientific Career Development offer diverse mentoring and career development opportunities.

 

A post-doctoral research fellow position is available in the Hatch Lab in the Basic Sciences Division. We study the structure and dynamics of the human nuclear envelope, with a primary interest in why and how nuclear membranes rupture and repair, and how defects in nuclear membrane stability impact cancer development (Gunn, Yashchenko, and Hatch, bioRxiv, 2023, DiPeso et al., bioRxiv, 2023, Mammel, Gunn, and Hatch, LSA, 2021; Maciejowski and Hatch, Ann Rev Cell Dev Biol, 2020). The Hatch lab uses a variety of techniques to achieve these goals with a focus on microscopy, automated image analysis, and cell-based tool development.

Responsibilities

The fellow will be responsible for defining, in discussion with Dr. Hatch, and executing a project related to the core interests of the lab with the goal of developing a new line of inquiry that the fellow could start their own research program with, if desired. Current areas of interest are: identifying and characterizing the molecular mechanism of proteins that regulate nuclear membrane rupture and repair, determining how chromatin regulates nuclear lamina organization and membrane stability in micronuclei, identifying and defining the mechanisms of the cellular consequences of micronucleation and nucleus rupture, and developing new models to investigate how nuclear rupture and micronucleation impact cell transformation and tumor progression. The development of collaborative projects with other labs at Fred Hutch is of substantial interest. The fellow will also be required to apply to relevant fellowship opportunities within the Hutch and from outside organizations.

 

Strong candidates will have demonstrated excellent abilities to independently design, execute, and interpret experiments, synthesize literature into working models, identify and communicate with scientists outside their lab to learn new techniques or topics, and effectively communicate the significance of their research in oral and written presentations.

 

Qualifications

• A PhD in biology is required.
• First authorship on a published manuscript, or one in submission, is required.
• The ability to clearly and efficiently communicate data, both in writing and verbally, is required.
• The ability to work independently is required.
• Experience with microscopy and quantitative image analysis is strongly preferred.
• Experience with immunological labeling techniques, including western blotting, flow cytometry, a