Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms

<div class="content-intro"><p><strong>JOIN US!</strong></p> <p>Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at <a href="https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.adicetbio.com&esheet=54175567&newsitemid=20250108585728&lan=en-US&anchor=https%3A%2F%2Fwww.adicetbio.com&index=1&md5=9d942dbcdb299f0c9fe719a48148cd0e">https://www.adicetbio.com</a>.</p></div><p><strong>Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms</strong></p> <p><strong>Contract Duration: </strong>One year</p> <p><strong>Why this matters:</strong></p> <p>This role accelerates cell and genome therapy research by enabling reliable generation, characterization, and improvement of lentiviral vectors used in discovery and preclinical studies.</p> <p><strong>The Opportunity</strong></p> <p>We are seeking a highly motivated Senior Research Associate / Associate Scientist (BS/MS) to advance lentiviral vector research with some early process development. This is a 100% bench-based, hands-on laboratory role focused on running, troubleshooting, and improving upstream and downstream LVV workflows to enable discovery and preclinical studies.</p> <p><strong>Hands-on, bench role</strong>: This position is primarily lab-based and focuses on molecular biology, library design/generation for screening mammalian/phage display or related, lentiviral vector production, and T cell / immune cell workflows. Success in this role requires strong experimental execution, troubleshooting, and clear ELN documentation.</p> <p><strong>Key Responsibilities</strong></p> <ul> <li>Design, build, and QC DNA constructs and variant libraries for screening (e.g., mammalian/phage display), including cloning strategy and library design influenced by structure-function analysis.</li> <li>Produce, titer, and QC lentivirus from HEK293T or derivatives; optimize transfection and harvest conditions to improve yield/quality.</li> <li>Perform mammalian tissue culture (maintenance, banking, transfection/transduction) in BSL-2; support scale-up as needed (cell factories and/or single-use bioreactors, where applicable).</li> <li>Execute immune cell workflows as applicable (PBMC/T cell isolation, activation, gene delivery, expansion) and support functional characterization.</li> <