Principal, Machine Learning Engineer

<p><strong>Your Impact at LILA</strong></p> <p>Lila is building a platform where AI and automation co-evolve to solve the hardest problems in medicine. Within Life Science AI (LSAI), ML engineers build and operate the systems that turn generative models and reasoning frameworks into production capabilities powering automated scientific discovery across Lila's life science domains.</p> <p>We are seeking a Principal ML Engineer to design, build, and scale the ML infrastructure behind models spanning biological sequence design, molecular structure prediction, antibody engineering, and multimodal scientific reasoning. You will own critical systems end to end, from training pipelines and distributed compute to model deployment and integration into Lila's closed-loop discovery engine.</p> <p>This is a high-impact IC role for someone who operates at the intersection of ML systems engineering and life science applications. You will shape the technical direction for how ML models are trained, evaluated, and deployed at scale, collaborate closely with AI scientists and experimental researchers to close the computational-experimental loop, and drive Lila's ML infrastructure toward the next generation of capabilities.</p> <p><strong>What You'll Be Building</strong></p> <ul> <li>Design, build, and optimize large-scale training pipelines for generative models on biological and chemical data, including distributed training across GPU clusters</li> <li>Own production ML systems end to end: model deployment, serving infrastructure, monitoring, and reliability for models used in Lila's scientific workflows</li> <li>Architect ML infrastructure that supports rapid iteration across sequence design, structure prediction, and multimodal scientific reasoning workloads</li> <li>Drive the engineering side of Lila's "Lab-in-the-Loop" lifecycle: build pipeline models, integrate experimental feedback loops, and ensure model outputs are actionable for downstream scientific workflows</li> <li>Define and advance ML engineering standards, tooling, and best practices across the AI organization</li> <li>Collaborate with AI scientists to translate research prototypes into robust, scalable production systems, bridging the research-to-deployment gap</li> </ul> <p><strong>What You’ll Need to Succeed</strong></p> <ul> <li>Master's degree or higher in Computer Science, Machine Learning, or a related quantitative field (or Bachelor's with equivalent professional experience)</li> <li>10+ years of hands-on experience building and operating production ML systems at scale</li> <li>Deep expertise in distributed training infrastructure, including experience with large-scale GPU clusters (AWS, GCP, or on-prem)</li> <li&g