Associate Principal Scientist/Associate Director

We are seeking a highly motivated and independent Associate Principal Scientist/Associate Director with experience in hematology-oncology and a track record of scientific excellence to join our In Vivo Pharmacology Team in Waltham, MA, USA. As an Associate Principal Scientist/Associate Director, In Vivo Pharmacology, you will be leading research to evaluate the efficacy and mechanisms of action of small molecules in hematology-oncology. You will utilize your cancer biology experience and practical expertise to generate robust datasets that will have a direct impact on the oncology drug discovery process and drug pipeline. 

Key Duties and Responsibilities: 

Working in this one-site laboratory-based position within the Hematology Oncology In Vivo Pharmacology Team, you will develop, design, conduct and analyze both in vivo and in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will be expected to collaborate with cross-functional teams including representatives from Translational Medicine, DMPK, Pharmsci, and Safety. You will work collaboratively with project leaders to ensure timely generation, and dissemination of critical program data. As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in hematology biology, pharmacology and cancer modeling and have a genuine passion for this field of research.  In addition, you will be responsible for leading a cross-functional working group focused on development and optimization of heme in vivo models in addition to biomarker assays for analysis of in vivo samples. Critical to this role is organizational and communication both within the in vivo team and the broader AZ organization. 

Minimum Requirements: 

• Ph.D. with >5 years of research experience in biotechnology or pharmaceutical industry in small molecule drug development and effectively lead multiple projects from an in vivo perspective. 

• Experience developing and working with hematological oncology in vivo models, such as xenograft (subcutaneous and luc-tagged disseminated models), disseminated patient derived xenograft (PDX), and humanized mice.  

• Demonstrated experience delivering in vivo pharmacology data packages for small molecule programs in rodents tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies. Experience with developing executable studies to persecute combinations strategies with small molecules and biologics.   

• Working knowledge with a range of in vitro skills, e.g. cell culture, molecular biology, immunoblotting, flow cytometry (spectral preferred), MSD, and ELISA.  

• Excellent communication, organizational, presentational, and listening skills are required. Must be able to be flexible and adaptable to AstraZeneca “ways of working.” Ability to drive, manage, execute and present results for oncology small molecule projects to project teams, key stakeholders and leadership.