Executive Director / Senior Director, Project Management Lead

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

Position Overview 

The Executive Director / Senior Director, Project Management Lead is responsible for leading and developing Immunome’s Project Management function and ensuring consistent, high-quality project management support across Research and Development programs and functional teams. This role focuses on strengthening alignment, transparency, and execution discipline across cross-functional and program teams, while establishing scalable project management standards, governance practices, and enterprise tools.  

The Executive Director / Senior Director will oversee the project management team, ensure consistent application of planning and reporting frameworks, and partner closely with functional and program leadership to drive operational cohesion across the organization. This role will also lead Immunome’s Smartsheet platform strategy to ensure standardized communication, reporting, and project visibility across programs and functions.  

This role is ideal for a seasoned project management leader who excels at building high-performing teams, driving consistency across diverse functions, and leveraging enterprise tools to enhance transparency and execution discipline. The Executive Director / Senior Director, Project Management Lead will be instrumental in ensuring Immunome’s programs and functional initiatives are supported by standardized, scalable, and aligned project management practices.  

This position reports to the Senior Vice President of Project and Program Management and plays a key role in reinforcing organizational alignment and execution excellence.  

Responsibilities 

Project Management Team Leadership  

• Lead, mentor, and develop the Project Management team, including hiring, onboarding, coaching, and performance management.  

• Establish clear role definitions, expectations, and accountability standards for project managers embedded within program and functional teams.  

• Ensure consistent training and capability development across the PM team.  

• Assess PM capacity and align resources with evolving program and functional priorities.  

• Foster a culture of rigor, transparency, and continuous improvement within the PM function.  

 

Cross-Functional & Program Team Alignment  

• Partner with leaders across Research, Clinical Development, CMC, Regulatory Affairs, Commercial, Finance, and other operational groups to ensure consistent planning, milestone definition, risk tracking, and reporting practices.  

• Drive alignment between program teams and functional teams to ensure shared visibility into timelines, dependencies, decision points, and resource needs.  

• Standardize integrated planning processes to reduce variability in execution across programs.  

• Ensure transparent identification and management of cross-functional risks and interdependencies.  

• Facilitate structured governance interactions and clear escalation pathways across teams.  

• Smartsheet Platform Leadership & Execution Transparency  

• Lead the strategy, governance, and optimization of Immunome’s Smartsheet platform to support project and program management needs.  

• Establish standardized templates, dashboards, and repo