Director - Target Discovery Biology (TD&B)

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

R-239403 Director - Target Discovery Biology (TD&B)

Let’s do this. Let’s change the world. n this vital leadership role, you will join Amgen’s Target Discovery & Biology (TD&B) organization within DATA, helping to define and deliver the next generation of discovery biology. TD&B integrates perturbation technologies, multi-omics profiling, regulatory genomics, human genetics, and advanced disease models to uncover novel therapeutic targets and deep biological insights that fuel Amgen’s mission to serve patients.

As Director, you will lead a multidisciplinary discovery organization spanning functional perturbation biology, viral technologies, high-throughput screening, and advanced cellular model systems. Together, these capabilities form a core engine for the identification of novel therapeutic targets across Amgen’s therapeutic areas. This role also sits at the intersection of human genetics and experimental biology, driving systematic functional interrogatoin of genetic hypotheses and building scalable discovery platforms that accelerate target identification and validation.

Key Responsibilities:

Lead and Inspire

• Provide scientific and strategic leadership for perturbation-based discovery platforms to drive innovation in target identification and mechanistic biology.
• Oversee cell technology and model development efforts, including cell engineering, complex in vitro systems, and viral technology platforms.
• Guide and mentor team leaders and their lab in setting priorities, developing talent, and executing high-impact discovery programs.
• Build a culture of scientific curiosity, technical excellence, and collaborative discovery across multidisciplinary biology and technology teams.

Collaborate and Integrate

• Partner closely with therapeutic area leaders across Amgen, particularly within inflammation, oncology, metabolism, and cardiovascular research, to align priorities and identify new target opportunities.
• Work collaboratively with TD&B and DATA colleagues to integrate human genetics, regulatory genomics, perturbation biology, and multi-omics profiling to drive end-to-end discovery.
• Collaborate with Amgen’s deCODE Genetics (ADG)  team to translate genetic signals into mechanistic insight through variant-to-gene-to-function discovery strategies.
• Serve as a scientific connector across discovery platforms, ensuring insights from genetics, profiling, and perturbation studies inform target discovery and validation efforts.

Innovate and Advance

• Drive innovation through the implementation next-generation perturbation approaches, including pooled and arrayed screening, combinatorial perturbation strategies, and emerging in vivo functional genomics approaches.
• Champion the adoption of automation, AI/ML, and scalable discovery technologies to enhance throughput, data integration, and reproducibility.
• Contribute to strategic planning and portfolio prioritization, ensuring TD&B capabilities continue to enable Amgen’s long-term discovery strategy.
• Represent TD&B internally and externally through scientific presentations, collaborations, and publications.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

Doctorate degree and 4 years of relevant industry experience

OR

Master’s degree and 8 years of relevant industry experience

OR

Bachelor’s degree and 10 years of relevant industry experience

In addition to meeting at least one of the above requirements, you must have at least 4 years experience directly managing people and/or leadership exper