Research Staff Scientist - Neurosurgery

SHIFT:

Day (United States of America)

Seeking Breakthrough Makers

Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career.

CHOP’s Commitment to Diversity, Equity, and Inclusion

CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.


A Brief Overview
This role is an advanced researcher that plans, coordinates and executes complex research projects. Contributions are scientific or intellectual, characterized by originality and creativity. Works under the mentorship of an established principal investigator to conduct research in a specific scientific area. Conducts experiments without direct supervision; develops research projects with the guidance of the principal investigator. Develops new experimental procedures and hypotheses for further investigation.

Prepares manuscripts and abstracts for publication, publishes scientific articles in refereed journals, presents at scientific symposiums. Collaborates and interacts with other researchers within CHOP - RI and at other institutions. Assists in the preparation of scientific publications and research grant proposals. Serves as resource person for colleagues and as a mentor for less experienced research personnel. May manage/supervise other research staff or projects; assists with the management of laboratory operations.

About The Laboratory

Research Scientist Position in Translational Pediatric Brain Tumor Research

A Research Scientist position is available in the laboratory of Dr. Peter Madsen, MD, Assistant Professor of Neurosurgery and Oncology. As a pediatric neurosurgeon, he is dedicated to the care of children and young adults with brain tumors. Dr. Madsen’s complimentary translational laboratory is part of the Center for Data Driven Discovery in Biomedicine (D3b) of the Division of Neurosurgery at the Children’s Hospital of Philadelphia (CHOP), the Center for Childhood Cancer Research at CHOP, and the University of Pennsylvania (UPENN). This position will be a part of a research program that aims to develop and enhance immunotherapeutic approaches for pediatric brain tumors, from generation and analysis of bioinformatic data, development of advanced modelling systems, and preclinical testing of therapies destined for the clinic or operating room. The laboratory uses cell line, organoid, and both xenograft and syngeneic mouse models to recapitulate various pediatric brain tumors and test novel therapeutics. Our main focus is on developing chimeric antigen receptor (CAR) T cell approaches for pediatric brain tumors. We also investigate new methods of CAR T cell delivery and advanced microscope imaging techniques to study CAR T cell trafficking in the brain. This highly translational work will be used to inform clinical trials for pediatric patients.

Strong experimental skill in basic molecular biology techniques are a prerequisite (DNA, RNA, protein analysis, cloning, cell culture, multi-parameter flow cytometry, cytotoxicity).

Strong preference will be given to candidates with at least two or more of the following specific skills:

• Experience in mouse brain tumor models, including stereotactic surgery
• Experience in genetically engineered models of cancer, including breeding, neonatal surgery, and colony maintenance
• Experience in advanced confocal or lightsheet microscopy
• Experience in advanced in vivo imaging techniques including IVIS and MRI
• Experience in adoptive cellular therapeutics
• Experience in bioinformatic techniques, particularly proteomics

The successful candidate will:

• Plan, conduct, and manage research projects within the federal and institutional regulations and policies
• Assist the PI in the conduct of research of significant value in the basic and/or translational science area
• Collaborate with researchers, external agencies and institutions to develop cooperative research initiatives around immunotherapy for pediatric brain tumors
• Order resear