Project Lead, Senior Scientist, Global DMPK&M

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as Senior Scientist, DMPK Project Lead in our Cambridge, Massachusetts office. As a member of Global DMPK organization, you will also have cross-site interactions.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

As a DMPK Project Lead for a diverse range of therapeutic modalities including: cell therapy, T-cell engager, biologics, oligonucleotides, and small molecules, you will be empowered to create and communicate a clear DMPK strategy and champion novel scientific approaches in support of Drug Discovery and Development for programs in the Takeda Portfolio.

• Acts as a DMPK functional leader on project teams responsible for overseeing and managing research activities within the DMPK department including assigned projects; developing and integrating the DMPK strategy to progress drug discovery programs.
• Ensures selection and utilization of appropriate in vitro, in vivo and/or in silico methods and models to address absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic (PK)-related issues across several therapeutic areas, including: Oncology, GI, Neuroscience and all therapeutic modalities, but most specifically related to biologics, cell therapy, and oligonucleotide therapies.
• Independently designs studies, collaborates across functions, implements extensive scientific research projects and plans within DMPK, and provides leadership to the project teams. Contributes to multiple projects, acting as senior scientific subject matter expert, and may be a project team leader and/or provide key technical knowledge to a project team.

ACCOUNTABILITIES 

• Establishes project direction through integrating science, key technical knowledge, and program objectives
• Provides leadership to enable project teams to make informative decisions regarding selection and stage up of discovery compounds for pre-clinical development in Oncology, GI and Neuroscience areas
• Actively contributes to the evaluation of potential drug candidates for in-licensing
• Contributes to the preparation/editing/review of documents for regulatory submission (i.e., study reports, IB’s, IND’s)
• Independently and/or collaboratively conducts PK and PK/PD analyses during late-stage lead optimization through early pre-clinical development and collaborates in PK/PD and efficacy study design to support clinical dose setting
• Provides strategic and hands-on leadership relating to PK and ADME issues for diverse modalities including but not limited to T cell engagers, cell therapies, biologics and oligonucleotides
• Develops and mentors junior DMPK team members

DIMENSIONS AND ASPECTS

Technical/Functional (Line) Expertise

• Demonstrates well-developed knowledge of other disciplines/departments and how they function together
• Demonstrates exceptional project management skills and/or broad recognition for
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