Scientist, In Vivo Process Development Downstream

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Job Description

The Scientist, In Vivo Process Development Downstream role designs and executes downstream/purification experiments to support development of manufacturing processes for Lentivirus.

This role applies advanced chemistry, biochemistry, and/or engineering principles to deliver robust, scalable processes, supports manufacturing activities and process optimization at scale, and operates with broad autonomy and limited oversight. The Scientist is accountable for end-to-end process performance, scientific soundness, and technical leadership while training and mentoring colleagues.

Key Responsibilities

• Design and optimize scalable, safe, and cost-effective downstream process for Lentivirus manufacturing.
• Develops technical solutions to complex problems requiring ingenuity and creativity, applying advanced scientific/engineering principles to ensure scientific soundness and performance.
• Supports manufacturing activities and process optimization at scale, contributing technical expertise to improve process performance and scalability.
• Manages day-to-day laboratory operations, including planning work, maintaining efficient lab execution, and ensuring effective documentation practices.
• Keep accurate, detailed laboratory records and comply to all required training and safety guidelines.
• Apply statistical methodologies and basic modelling approaches to design experiments, perform data analysis, and interpret data.
• Trains, guides, and mentors colleagues by sharing technical skills, coaching on process execution, and troubleshooting, and strengthening team capability.
• Communicates technical outcomes in technical reports and presentations
• Interface with multidisciplinary groups  to solve complex issues and promote collaboration.
• Works independently with broad autonomy and limited oversight; determines approaches for moderately complex assignments under minimal direction.

Education and Experience

• B.S., M.S, PhD/PharmD in science or engineering
• BS with 6+ years post-graduate relevant experience in bioprocess/biotechnology, or
• MS with 4+ years post-graduate relevant experience in bioprocess/biotechnology, or
• PhD/PharmD

Required Qualifications

• Must have strong scientific understanding and demonstrated hands-on proficiency of downstream unit operations for large biomolecules (e.g. protein, virus) such as chromatography and filtration.
• Sound understanding of bioprocess scale-up principles for large biomolecules
• Working knowledge of cGMP principles
• Proficiency in Microsoft Word, Excel, Power Point, and data analysis software such as JMP, GraphPad
• Proven ability to collaborate in a dynamic team environment
• Excellent interpersonal, verbal, and written communication skills
• Strong organization and problem-solving skills with excellent attention to details

Preferred Experience and Skills

• Prior experience with process development of viral vectors
• Prior experience with the use of Design of Experiments (DOE) to support process development experiments.
• Prior experience with fermentation/cell culture and analysis of large biomolecules
• Hands-on experience with large scale bioprocessing in either non-GMP or GMP setting
• Demonstrated mentorship and team leadership

 

The salary range for this position is: $133,195.00 - $172,370.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsor