Senior Director, Therapeutic Area (Hepatology)

Sr Director Therapeutic Area (Hepatology)- US- Remote

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development

Senior Director, Drug Development & Consulting – Hepatology

At ICON plc, we are driven by commitment to People, Clients, and Performance. We are seeking a strategic Hepatology expert to join our Drug Development & Consulting team in a highly visible, client-facing role.

This position offers the opportunity to act as a trusted advisor to senior stakeholders across the industry, including CEOs, CMOs, and other Hepatology Therapeutic Area Heads. You will deliver bespoke, asset-centric solutions while shaping Hepatology drug development strategies across the full lifecycle.

The Role

This is a consultative and advisory role where you will serve as a key scientific partner to both external clients and internal teams. Often acting as the first technical point of contact, you will play a critical role in pre-sales activities, proposal strategy, and long-term partnership development within Hepatology.

Key Responsibilities

• Lead strategic Hepatology drug development program design, delivering tailored, asset-focused solutions across liver diseases including MASLD/MASH, alcohol-associated liver disease (ALD), cirrhosis, viral hepatitis, and other chronic and rare liver conditions like PBC, PSC, PFIC

• Own end-to-end protocol development, including design, scientific review, and evaluation for Hepatology clinical trials across Phases I–IV

• Partner directly with senior client stakeholders (e.g., CMO, TA Heads, Clinical Development leadership) to provide expert guidance on Hepatology development strategy and data interpretation

• Act as scientific and strategic lead in proposal development, study strategy, and bid defense activities within Hepatology

• Build and maintain strong relationships with Hepatology key opinion leaders (KOLs), advisory boards, and relevant regulatory authorities

• Contribute to the development of Hepatology-focused service offerings, supporting innovation and growth in liver disease drug development capabilities

• Provide training, mentorship, and thought leadership in Hepatology to internal teams and external partners

• Participate in portfolio reviews, governance discussions, and scientific oversight of Hepatology programs

• Support operational teams with high-level scientific input, including investigator meetings and Hepatology-specific study discussions

• Represent the organization at Hepatology congresses and scientific forums to promote clinical excellence and scientific leadership

What You Bring

• Deep, recognized expertise in Hepatology and liver disease drug development

• Strong understanding of Hepatology clinical trial design, biomarkers, endpoints (e.g., fibrosis staging, histologic and non-invasive markers), and evolving therapeutic landscapes (e.g., MASLD/MASH, alcohol-associated liver disease (ALD), cirrhosis, immuno-Hepatology approaches and antiviral therapies)

• Proven ability to operate in a strategic, client-facing, consultative environment within pharmaceutical or clinical research settings

• Experience engaging and influencing senior scientific and clinical stakeholders across industry and academia

• Excellent communication and presentation skills, with the ability to translate complex Hepatology data into clear, actionable development insights

• Collaborative, global mindset with strong cross-functional leadership capability

• MD required, ideally with specialization or substantial clinical/research experience in Hepatology

Additional Information

• 20- 40% travel (domestic and international)

• Opportunity to work in a highly visible, impact-driven role shaping the future of Hepatology drug development

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What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements

• A range