Senior Director, Protein Sciences

Company Overview:

Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. For more information, please visit https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. 

Role Summary:

Dyne is seeking a talented and highly motivated Senior Director to advance the discovery and development of new therapeutic molecules for rare genetic disease. The candidate will ensure technical excellence in protein design and production, drive innovation to extend Dyne’s FORCE® platform, and provide leadership to an interdisciplinary group of scientists.

The ideal candidate will have broad technical knowledge of fundamental protein sciences, extensive experience in protein therapeutics discovery and development, and exceptional leadership ability. They will manage internal and external resources to design, produce, and characterize antibodies, antibody conjugates, and antibody fusion proteins to advance Dyne’s pipeline. They will communicate scientific progress and business needs across multiple functions, including Research, CMC, and Legal. They will work with work with a collaborative, constructive and mission-oriented focus to contribute to an inclusive culture and to improve the lives of patients.

This role is based in Waltham, MA without the possibility of being fully remote.

Primary Responsibilities Include:

• Support protein design, production, and characterization across drug discovery and development projects from conception to lead identification to development candidate nomination.
• Lead a team of technical experts to design, produce, and characterize proteins as candidates, either as standalone therapeutics or as conjugates.
• Support discovery of antibodies and related binder molecules as therapeutics or tools for biomarker, toxicological, or other investigational purposes.
• Seek out opportunities for new therapeutic projects that leverage the company’s core competencies and Platform capabilities to deliver value to patients.
• Conceive, negotiate, and execute research projects with external vendors according to business needs.
• Work effectively with other disciplines including chemistry, disease biology, and safety/toxicology to generate and communicate preclinical data in support of therapeutic development.
• Prepare reports, protocols, and other documentation to support clinical development and manufacturing of lead therapeutic candidates.
• Communicate progress and business needs within Research and cross-functionally.
• Continuously improve the operational effectiveness of the Platform Development group by improving processes, disseminating knowledge, and mentoring others as scientists and leaders.
• Contribute to building a positive, team-oriented culture.

 

Education and Skills Requirements:

• Minimum PhD in Biochemistry, Molecular Biology, or related discipline.
• Minimum 10 years of relevant experience in drug discovery and development focused on antibody/protein therapeutics, preferably in a clinical stage biotechnology company.
• Strong practical knowledge of design, production, and development of therapeutic proteins across multiple modalities, including early stage cell line development and/or technology transfer to external manufacturing partners.
• Excellent project, time management, and problem-solving skills.
• Proven leadership and interpersonal skills.
• Experience leading research stage drug discovery projects.
• Strong track record of scientific accomplishments with relevant publications and presentations.
• Excellent written and verbal communication skills, including making effective and compelling presentations in both large and small groups and communicating complex scientific and nonscientific issues to program teams.
• Ability to critically evaluate, summarize, interpret data.
• Ability to understand published scientific literature outside of their immediate area of expertise and appropriately apply this to company priorities
• Prepare manuscripts and other documents