Scientific Director – Pathologist, Translational Pathology, Precision Medicine

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientific Director – Pathologist, Translational Pathology, Precision Medicine

What you will do

Let’s do this. Let’s change the world. The use of Biomarkers and Diagnostics is central to understanding how our therapeutics work and identifying patients that benefit most from these therapies. Accordingly, the Precision Medicine (PMED) function plays a critical role in advancing our drug development programs and is accountable for the development of biomarker and diagnostics strategy across our pipeline. The PMED Translational Pathology group is responsible for implementing the biomarker and diagnostics strategies. We are seeking a highly motivated individual to provide pathology expertise and help drive implementation of tissue-based assays including digital pathology solutions to support diagnostics and biomarker strategies. This individual will work closely with internal groups and external CROs/collaborators. This position will report directly to the Executive Director of Translational Pathology.

In this vital role you will successfully partner with cross-functional stakeholders to drive implementation of biomarker and diagnostics assay development

• The Translational Pathology Director will be accountable for the scientific strategy for and implementation of translational tissue-based biomarkers including patient selection, pharmacodynamic, and mechanism of resistance.
• The Translational Pathology Director will work closely with the computational imaging group to develop digital pathology/AI algorithms for IHC and/or H&E stained slides from clinical trial tissues across therapeutic areas.
• The Translational Pathology Director will provide expertise in human disease pathology and experimental pathology for development and interpretation of tissue-based assays.
• The Translational Pathology Director will be accountable for delivering internal and external patient selection IHC and Molecular Dx assays and cutoffs across therapeutic areas through management of individual contributors, cross-functional relationships and external partnerships.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

DVM OR MD [and relevant post-doc where applicable] and 5 years of translational or experimental pathology experience

Or

Master’s degree and 8 years of translational or experimental pathology experience

Or

Bachelor’s degree and 10 years of translational or experimental pathology experience

Preferred Qualifications:

• Highly experienced pathologist (MD or DVM degree) with 5+ years of relevant postdoctoral academic, clinical and/or industry pathology experience. PhD in addition to professional degree is a plus but not a requirement. Board certification in the United States is desirable but not required.
• A proven translational pathology track record with credible publications and strong molecular and/or experimental pathology supporting research and development
• Demonstrated expertise in tissue-based analysis such as in situ hybridization, immunohistochemistry, fluorescence applications, laser capture microdissection
• Expertise with human diseases and experimental mouse models
• Expertise with image analysis software and algorithm design
• In depth experience with the discovery, characterization, clinical validation, and utilization of tissue-based diagnostics
• Awareness of the challenges of implementing tissue-based biomarker and diagnostic technologies in the clinical setting
• Direct experience in development, outsourcing and validation of clinically applicable tissue based diagnostic assays
• Demonstrated excellence in independ