Senior Scientist, Lead Evaluation and Cellular Pharmacology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacology

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Scientist, Lead Evaluation and Cellular Pharmacology to be located in San Diego, CA.

Purpose: The Lead Evaluation and Cellular Pharmacology team is a part of the Discovery Technologies and Molecular Pharmacology (DTMP) organization, a critical group in the larger Discovery Sciences organization. We are committed to the delivery of high-quality chemical leads and clinical compounds in the three Johnson & Johnson Innovative Medicine therapeutic areas. This position requires deep scientific expertise in multiple fields including cellular pharmacology, assay development, compound profiling, in vitro/ex vivo technologies, and imaging capabilities with an ability to work collaboratively with internal and external partners.

You will be responsible for:

• Learn and apply state-of-the-art drug discovery approaches in a multidisciplinary team
• Develop, troubleshoot, and validate functional cell-based, cell-free, and ex vivo assays
• Profile compounds to enable medicinal chemistry SAR studies
• Profile compounds in various organotypic models
• Collaborate across multiple therapeutic teams and functional areas
• Analyze data and present results at program team meetings
• Attend and present data at internal meetings and external scientific conferences

Qualifications / Requirements:

Education: Minimum of a Bachelor's degree in cell biology, biochemistry, or related field is required. Advanced degree is preferred.

Skills/Experience:

Required:

• A minimum of 6 years of experience is required.
• Expertise using and creating state-of-the-art cell-based, cell-free, and ex vivo assays
• Prior knowledge troubleshooting assays, processes, and logistics to seamlessly implement new assays across different modalities
• Extensive experience with cell culture and associated techniques
• Broad hands-on experience with rodent handling across a wide range of ages
• Deep expertise with multiplex imaging & immunofluorescence methods
• Deep understanding of cellular biology and pharmacology
• Proficiency with standard scientific software used for data analysis (e.g. GraphPad Prism, Genedata Screener, Perkin Elmer Signals, and Spotfire)
• Excellent written/verbal communication and oral presentation skills
• Ability to adapt to a fast-advancing environment in an independent manner

Preferred:

• Hands-on experience with stable cell line creation
• Prior management experience is a plus
• Familiarity with high-content imaging platforms (such as Opera Phenix imagers) and associated software and data analysis packages
• Detailed understanding of small animal anatomy
• Expertise with laboratory automation and high-throughput screening
• Working knowledge in immunology, neuroscience, and/or oncology therapeutic areas

The anticipated pay range for this position is $105,000 to $169,050.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual perf