Associate Principal Scientist, Discovery Oncology

Job Description

We are seeking a highly motivated and innovative Associate Principal Scientist to join our Discovery Oncology team in South San Francisco. The successful candidate will have a strong track record in oncology and drug discovery and will lead the conception, design, and execution of discovery-stage research programs. In this role, you will partner closely with cross-functional teams across the organization to advance differentiated cancer therapies from target validation through early development.

Key Responsibilities:

Design, establish, and optimize in vitro and ex vivo assays to elucidate mechanisms of action and assess therapeutic potential.

Make timely, data-driven decisions that balance innovation, risk, and experimental rigor

Communicate scientific strategy, rationale, and results clearly to internal teams and help build external scientific presence through publications, conference presentations, and collaboration

Drive ideation and early-stage discovery efforts to deliver competitive oncology programs, leveraging internal expertise and emerging technologies

QUALIFICATIONS:

Education:

• Ph.D. in Cancer Biology, Cell Biology, Pharmacology, Immunology, Biochemistry, or a related discipline with four (4) or more years of relevant oncology drug discovery experience

Required Experience and Skills:

• Deep expertise in tumor biology and immune oncology, including cancer genomics and oncogenic signaling
• Broad technical expertise in molecular and cellular biology, biochemistry, and analytical methods
• Extensive hands-on in vitro experience designing, executing, and analyzing multi-color flow cytometry and mechanistic cell-based assays (e.g., viability/cytotoxicity, cell cycle, signaling, and immune response readouts)
• Demonstrated ability to drive innovative research, evidenced by high-impact publications, patents, and/or successful advancement of discovery programs
• Passionate, creative, and collaborative scientist committed to improving outcomes for people living with cancer
• Excellent oral and written communication skills, a positive, team-oriented mindset, and strong leadership potential

Preferred Experience and Skills:

• Hands-on experience with different therapeutic modalities (e.g.,small molecules, mAbs,  ADCs and TCEs)
• Extensive hands-on experience designing, executing, and analyzing in vivo mouse model data to evaluate therapeutics

  #EligibleforERP 

Required Skills:

Biochemistry, Cancer Cell Biology, Cancer Research, Cell Biology, Immuno-Oncology, In Vitro Biology, In Vitro Research, In Vitro Studies, Molecular Biology, Oncology, Tumor Biology

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

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