Director, Toxicology

<div class="content-intro"><p>At Pliant, we believe differentiated science can make a meaningful impact. We see our success as a direct result of the central role that each team member plays in advancing our mission to develop therapies that target the disease at its source. We are seeking creative, curious and collaborative individuals who&nbsp;<strong>dare to succeed</strong>, are committed to&nbsp;<strong>making an important impact</strong>&nbsp;on patient’s lives and will help us build&nbsp;<strong>one Pliant</strong>!</p></div><h1><strong>Description</strong></h1> <p>The Director of Toxicology is a strategic and hands-on scientific leader responsible for shaping and executing nonclinical safety strategies across the discovery and development portfolio. Reporting to the Vice President of Nonclinical Development, this individual serves as the company’s nonclinical safety expert – driving the design, execution, and interpretation of toxicology and safety pharmacology programs from early research through regulatory submission.</p> <p>This role provides strong scientific and intellectual leadership across cross-functional teams, partners closely with internal stakeholders and external vendors, and represents nonclinical safety in interactions with global regulatory authorities. The ideal candidate is a collaborative, self-directed leader with deep industry experience across all stages of drug development, and a proven track record of U.S. and ex-U.S. regulatory submissions.</p> <h1><strong>Responsibilities</strong></h1> <ul> <li>Designs and oversees non-GLP and GLP nonclinical safety programs to advance Pliant’s pipeline of small and large molecule therapeutics for global submissions</li> <li>Develops and implements target de-risking and screening strategies in discovery teams to support safety lead optimization efforts</li> <li>Leads investigative efforts into mechanisms of toxicity as needed</li> <li>Serves as the nonclinical safety subject matter expert, contributing to cross-functional program strategy and decision-making</li> <li>Collaborates closely with internal cross-functional groups such as Pharmacology, ADME-PK, BA, CMC, Regulatory Affairs, Clinical Development, and Project Management</li> <li>Analyzes, interprets, summarizes, and presents nonclinical safety data to internal teams and senior leadership</li> <li>Authors and reviews safety pharmacology and toxicology sections of global regulatory documents for IND and post-IND stage programs and acts as a nonclinical point of contact for any information requests</li> <li>Represents the organization in interactions with global health authorities, including preparation for and participation in agency meetings</li> <li>Authors SO