Director, Metabolic Disease

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Director, Metabolic Diseases will drive departmental strategy and lead an in vivo team supporting all obesity programs. The candidate works closely with the Vice President, Metabolic Diseases, and other senior leaders to shape vision, prioritize tactical approaches, lead programs, develop talent, and build strong external relationships. The successful candidate will also draw on a strong background in drug development to support Discovery-wide efforts to strengthen the position of Crinetics as a world-class organization in GPCR-based therapeutics to treat endocrine and related diseases. This is an on-site position.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Serve as a Program Lead to guide, coordinate, and implement cross-functional activities for metabolic disease programs

• Contribute significantly to decision-making around therapeutic indications and differentiation strategies

• Contribute to long-term strategy in metabolic diseases

• Drive the identification, evaluation, and prioritization of new targets

• Supervise and develop a team of in vivo scientists

• Identify and lead external collaborations as needed

• Present data/strategy as appropriate at team/cross-functional meetings, corporate meetings, in KOL discussions, and at scientific conferences

• Other duties as assigned

Education and Experience:

Required:

• Ph.D. and 10+ years of relevant experience in the area of metabolic diseases

• 8+ years of supervisory experience; at least 5 years of experience leading an in vivo team

• 8+ years of experience in drug development in the area of metabolic diseases

• Strong knowledge of mechanisms relevant to energy balance and glucose homeostasis

• 5+ years of experience in program leadership role (program lead or in vivo lead)

• Experience the interpretation and prioritization of in vivo, ex vivo, and in vitro models relevant to obesity and diabetes

• Strong understanding of assay cascade optimization, the identification of development candidates, and IND-enabling studies

• Track record in bringing programs from hit-to-lead to development candidate

• Excellent ability to communicate in strategic and external settings

• Strong written and verbal communication skills and ability to work effectively in a multidisciplinary team environment

• Strong track record in talent development

• Ability to work in a distributed workforce environment

• Ability to work in a fast-paced environment and adapt to change

Preferred:

• Significant background in GPCR drug development

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.

Travel:

You may be required to travel for up to 5% of your time.

The Anticipated Base Salary Range:  $183,000 - $229,000

In addition to your base pay, our total rewar