Postdoctoral Researcher, Jain Lab

<p><strong>About Arc Institute</strong></p> <p>Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.</p> <p>Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they're free to pursue high-risk, long-term research without commercial pressures. Arc's Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.</p> <p>Our two Institute Initiatives reflect this model in action:</p> <ul> <li><a href="https://arcinstitute.org/virtual-cell-initiative"><strong>Virtual Cell Initiative</strong></a><strong>:</strong> Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets,&nbsp; accelerating the path from biological insight to clinical trials.</li> <li><a href="https://arcinstitute.org/alzheimers-disease-initiative"><strong>Alzheimer's Disease Initiative</strong></a><strong>:</strong> Mapping the genes, pathways, and environmental factors behind Alzheimer's disease to develop drug candidates that address root causes.</li> </ul> <p>More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.</p> <p><strong>About the position</strong></p> <p><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__ishajainlab.com_&amp;d=DwMF-g&amp;c=iORugZls2LlYyCAZRB3XLg&amp;r=vNfva3Zcxin30zKAYt_noLb6dTqLO9YBIU9maXLKVgc&amp;m=b7Q1OMvGii23FwRK-OoLUQBCXtY-Iv2b3lg6TRHv7n0&amp;s=4LclCVUYC_syLsZYmGpVfdJTbpdN6zNlyn-sI3wu3Vk&amp;e=" target="_blank">The Jain Lab</a> is looking for motivated, hard-working and curious applicants. At a high level, we study how organisms interact with their environments – how “what we breathe” and “what we eat” affects our metabolism and disease progression. More specifically, we are focused on oxygen and vitamin/cofactor metabolism. We recently discovered that chronic hypoxia (equivalent to living in the mountains of Peru or Nepal) can serve as a therapy for mitochondrial disease. This approach is currently in clinical trials. This work has inspired a broader set of research directions ranging from fundamental biochemistry to animal physiology.</p> <p>The questions we ask:</p> <ol> <li>How do cells and organisms sense oxygen or vitamin levels? Are there novel oxygen sensors and vitam