Senior Scientist

Company Description

Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.

Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.

Recognitions

 

Consistently Ranked Science’s Top Employer

Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients. That’s why we’ve been named the No. 1 company to work for in the biopharma industry in Science’s Top Employers survey for four years in a row.

 

  

 

 

A Certified Great Place to Work®

We believe our company is truly special, and our employees agree. In July 2024, we became Great Place to Work-certified in the U.S. for the fourth year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, PEOPLE® Companies That Care, Best Workplaces for Women™, Best Workplaces for Millennials™, and Best Medium Workplaces™ lists.

  

 

Overview

The Senior Scientist will work within a multidisciplinary team of scientists focused on the design, engineering, and preclinical characterization of ground-breaking biotherapeutics. Specifically, the candidate will help lead engineering and optimization campaigns for a diverse array of biomolecular scaffolds including binding and targeting moieties, signaling molecules, enzymes, and biological drug delivery platforms.

Responsibilities

• Drive biomolecular engineering efforts within Insmed research projects, including strategy and methods development.
• Construct recombinant systems encoding protein variants and combinatorial protein libraries.
• Conceptualize, construct, qualify, and implement high throughput screening platforms to enable candidate selection from large panels and/or combinatorial libraries of engineered protein variants.
• Conduct precision protein engineering to achieve specified design objectives, working both independently and in collaboration with computational biologists.
• Devise, optimize, and employ tailored protein expression and purification strategies for drug discovery programs.
• Develop, qualify, and deploy quantitative functional assays to characterize protein performance in vitro.
• Assess therapeutic candidate performance using in vivo models.
• Contribute to collaborative prioritization and decision making on prospective discovery and development programs.
• Maintain accurate, detailed, and timely records of methods development, experimental data, and data analysis.
• Participate in cross-disciplinary mentoring and training within the RDL NH team.
• Present scientific results to the RDL NH team, Insmed research department, and external scientific community, as needed.
• Assist with coordination and day-to-day management of RDL NH site operations.

Qualifications:

• Minimum PhD and 5+ years experience OR MS and 9+ years’ experience in biochemistry, molecular biology, bioengineering, or related field.

Knowledge & Experience:

• Deep technical understanding of, and hands-on experience with, molecular biology, recombinant DNA technology, protein mutagenesis, and protein biochemistry.
• Expertise with recombinant protein expression and purification.
• Expertise with routine protein characterization methods including but not limited to spectroscopy, SDS-PAGE, western blot, ELISA.
• Experience with protein-protein binding analysis a must, and experience with enzyme analysis a plus.
• Proven track record in experimental methods development, including experimental design, execution, and evaluation.
• Experience in high throughput functional screen development for protein libraries strongly preferred.
• Experience with lab automation strongly preferred.
• Experience with next-generation sequencing strongly preferred.

Skills:

• PCR, molecular cloning, Cell culture (microbial and tissue culture), protein chromatography, BLI/SPR, ELISA, enzyme kinetics, electr