Postdoctoral Fellow - Structural Biology of the Cytoskeleton (Walton Lab)

Van Andel Institute (VAI), a world-class biomedical research institute, located in Grand Rapids, Michigan, is dedicated to improving human health. We are pioneers in the fight against cancer, Parkinson's, and other diseases. We are committed to inspiring the next generation of scientists and educators.

The Walton Laboratory at Van Andel Institute (VAI) is seeking a highly motivated Postdoctoral Fellow to lead cutting-edge research into the fundamental mechanisms of cytoskeletal regulation. Our work combines tissue-derived protein samples with state-of-the-art structural and biochemical approaches to uncover the molecular interactions specializing cytoskeletal network formation in different cell types and subcellular locations. Our goal is to understand how disease-causing mutations disrupt the spatial organization of cytoskeletal filaments and compromise essential cellular processes.

Applicants with previous experience in cryo-EM, or strong biochemists eager to pursue structural biology, are encouraged to apply.

Potential Research Projects

• Determine high resolution cryo-EM structures of microtubules and bound regulatory proteins
• Reconstruct 3D cytoskeletal networks by FIB-milling and cryo-ET
• Map protein-protein interactions by isolating cytoskeletal fractions from mammalian tissue

Responsibilities

• Design and execute experiments to purify and characterize protein complexes 
• Prepare and screen grids to optimize sample conditions
• Collect and analyze cryo-EM and cryo-ET data
• Build detailed structural models of cytoskeletal assemblies
• Communicate findings through publications and presentations
• Collaborate within the lab and with external partners to advance project goals
• Study and apply relevant background literature

Qualifications

• Ph.D. in biochemistry, biophysics, molecular biology, or a closely related field
• A record of peer-reviewed publications or preprints is preferred
• Experience in protein biochemistry or structural biology is preferred

Why choose the Walton Laboratory? 

As a young laboratory, your success is my priority. I am deeply committed to providing personalized mentorship to support your growth and accelerate your research. By joining my team, you’ll work at the forefront of structural biology research by developing novel tools and approaches for imaging and modeling cytoskeletal networks. As part of the Department of Structural Biology at VAI, we have direct access to Krios and Arctica cryo-EM microscopes, with exciting upgrades scheduled for installation later this year.

Why join Van Andel Institute as a Postdoctoral Fellow?

Postdoctoral Fellows are full-time employees and receive a competitive annual salary beginning at $70,000. Postdoctoral fellows are a crucial part of Van Andel Institute’s efforts to improve the health and enhance the lives of current and future generations. 

Along with the competitive salary, our Postdoctoral Fellows are eligible for VAI benefits, including:

·       Medical, dental and vision coverage

·       Employer-sponsored life and AD&D insurance

·       Additional voluntary life and AD&D insurance for employees and dependents

·       Short-term and long-term disability insurance

·       Flexible-spending accounts for health and child/elder care

·       401(k) retirement savings plans with employee/employer contributions

·       Paid vacation, holidays, personal days

·       Relocation Assistance

VAI recognizes that selecting where to complete a postdoctoral fellowship is a significant decision for postdoctoral fellows. VAI has a dedicated Office of Postdoctoral Affairs, which provides a comprehensive professional development program.

How to Apply

Please submit your online application together with a single combined PDF including the following:

·       Cover letter describing your research interests and career goals

·       Curriculum Vitae (CV) including a list of publications

·       Contact information for 3 professional references who are aware of your application

About Van Andel Institute

Established in Grand Rapids, Michigan, in 1996 by the V