Lead CLD (Cell Line Development)

Company Description

Dr. Reddy’s Laboratories Ltd. is a leading multinational pharmaceutical company based across global locations. Each of our 24,000 plus employees comes to work every day for one collective purpose: to accelerate access to affordable and innovative medicines because Good Health Can’t Wait.

We started in 1984 with a modest investment, 20 employees and a bold vision. Today, we have research and development centres, manufacturing facilities or a commercial presence in 66 countries. 

For nearly four decades, we have stood for access, affordability and innovation based on the bedrock of deep science, progressive people practices and robust corporate governance. As the pharmaceutical industry evolves and undergoes disruption, we see an opportunity – to strengthen our core further (the next steps) and to build the future (the new bets).

‘The Next and the New’ is how we aim to continue to be the partner of choice – purpose-driven, future-ready and sustainable.  Our aim is to reach over 1.5 Bn+ patients across the world by 2030 by growing our core businesses and building for the future with sustainability at the core of our purpose and strategy. Sustainability for us means operating in a manner that respects people, planet and purpose – helping us conserve precious resources, serve our patients, create value for stakeholders, give back to society, fulfil our potential and maintain our integrity and transparency

Dr Reddy’s maintains a work environment, free from discrimination and is an equal opportunity employer. We are committed to employ & nurture all qualified diverse workforce without regard to race, colour religion, nationality, sex, age, disability status, genetics, sexual orientation, gender expression, citizenship or any other characteristic or classification protected by applicable law(s) of the country we operate in. We treasure every talent, and recognize merit and diversity in our organization.

Job Description

Job summary
We are seeking a professional to design expression constructs, utilizing expression platforms to deliver cell lines expressing Biotherapeutics. The role involves developing methods for establishing and characterizing biotherapeutic cell lines, evaluating productivity and generational stability, collaborating internally for departmental objectives, and providing stable, high-expressing cell lines/banks through successful process and formulation development.

Roles & Responsibilities
• You will be responsible for designing and preparing vector constructs for cell line development, prioritizing activities, analyzing moderately complex data, and identifying/resolving technical or execution issues in experiments.
• Your role includes interacting with other department groups (process development, formulation development, and analytical development) to plan and prioritize activities, as well as driving and guiding the team to execute experiments with expected quality and within defined timelines.
• Additionally, you will explore scientific innovations and evaluate the implementation of new technologies to drive development, shorten timelines, and improve methodologies in cell line development as the industry evolves.
• You will be responsible for developing and designing methods to determine gene copy number and sequencing of the gene of interest in cell lines used in manufacturing and under development. You will analyze data, identify and troubleshoot issues, and prepare knowledge and technology transfer documents for cross-functional transfer of methods to characterize cell lines if needed.
• You will lead the development of the process for establishing master cell banks (MCB) for different product cell lines, including designing experiments, ensuring the distribution of responsibilities among the team, and interacting with various development and manufacturing functions and stakeholders to enable smooth execution of activities.
• You will also prepare document recording sheets for accurate and detailed data recording, facilitating the smooth transfer of knowledge and methods to the manufacturing department.
• You will be responsible for writing and reviewing technical reports related to establishing cell lines, determining their genetic stability, and establishing methods and acceptance criteria for MCBs.
• You will prepare knowledge transfer documents for methods of genetic characterization of cell lines under development, review SOPs for equipment operation and development activities, and enhance documentation systems for improved traceability.
• You will be responsible for serving as the liaison for the cell line development team in project meetings as a Subject Matter Expert (SME) to provide and obtain information, and ensure clarity regarding project/activity status and requirements from different depar