Post Doctoral Scholar

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Job Title:

Post Doctoral Scholar

Department:

Medicine | Dermatology

A Post Doctoral Scholar (1-year term, renewable annually up to 5 years based on funding availability) will conduct independent and collaborative research projects in the Kawasumi Lab at The Ohio State University primarily on skin cancer biology and skin cancer epigenetics in order to investigate what genomic and epigenomic abnormalities exist in skin cancer and how we can modulate DNA damage responses or epigenetic changes to inhibit skin cancer.

Under the direction of the PI (Dr. Masaoki Kawasumi), the Post Doctoral Scholar will study UV-induced DNA damage responses, UV-mediated skin diseases (skin cancer and lupus), skin disease epigenetics, exosomes, and 3D skin models. The goals of these studies are to elucidate molecular mechanisms by which cells sense UV-induced DNA lesions (CPD and 6-4PP) and activate biological processes such as ATR-Chk1 checkpoint signaling, DNA repair, mutagenic translesion synthesis, epigenetic changes and to dissect the molecular mechanisms by which genetic/epigenetic changes occur during cancer evolution, caffeine treatment, and UV-induced DNA damage and lupus development. Our approaches include cell culture (primary cells and established cell lines), flow cytometry, DNA replication track analysis, Western blot analysis, chromatin immunoprecipitation (ChIP), proteomics, next-generation sequencing and analysis, genome and epigenome editing, small-molecule screening, novel and established mouse genetic models, and patient-derived xenograft (PDX) models.

Critical skills include extensive, direct, hands-on experience with molecular and cellular assays, mouse studies, documenting research data, identifying technical problems and proposing solutions, taking team science approaches, next-generation sequencing data analysis, bioinformatics and statistical analysis, scientific writing, presenting data to various groups, aligning expectations and maintaining effective communication (including creating a mentoring compact and Individual Development Plan).

To be successful in this position, the Post Doctoral Scholar must be highly motivated with a track record of productive research, exemplified by publication(s) and presentations, and willing to discuss with the PI and collaborators, prioritize tasks, get things done on time and on budget, and work in a highly collaborative, open environment. This position is suited to someone who is eager to attend professional development workshops (including biomedical research integrity program) with a growth mindset and enjoys scientific writing, mastering new skills, multitasking, and working in a team environment. The Post Doctoral Scholar should have demonstrated ability to develop new and maintain existing collaborations with individuals within the research group as well as external collaborators, research coordinators, physicians, and scientists.

The Post Doctoral Scholar works as an experimenter, bioinformatician, and scientific writer. The Post Doctoral Scholar is responsible for mentoring junior members of the lab and providing technical and intellectual guidance and troubleshooting, ensuring scientific integrity by providing oversight as well as ensuring that efforts are distributed appropriately. The Post Doctoral Scholar will develop approaches and protocols as needed, while maintaining quality and cost effectiveness. The Post Doctoral Scholar will train junior scientists in specific, standardized techniques and inst