Post-Doctoral Research Fellow

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

A Postdoctoral Research Fellow training position is available to study the molecular mechanisms underlying nuclear hormone receptor biochemistry in the context of cancer development and treatment. The training will be mentored by Dr. Peter Nelson and members of his research group.

 

The particular areas of emphasis for this position center on studies of the processes contributing to the role of nuclear hormone receptor biology, particularly the androgen receptor (AR) in cancer development and treatment. The focus includes defining the molecular mechanisms by which nuclear hormone receptors regulate cell survival and proliferation programs. We are recruiting a post-doctoral fellow to engage in laboratory-based studies of these processes. This is a basic and translational science position that focuses on delineating molecular mechanisms with the opportunity for translational studies evaluating prevention strategies and determining the efficacy and outcome of novel therapeutics. Specific projects include studies of tumor cell metabolism, transcription factor biochemistry, epigenetics and drug development.

 

Training opportunities are provided through a highly multi-disciplinary research team that includes scientists with expertise in biochemistry, bioinformatics, single cell genomics, epigenetics, pharmacology and pathology. The laboratory website provides additional information: https://research.fhcrc.org/peternelson/en.html

 

Responsibilities

The particular areas of emphasis for this position center on studies of resistance to current therapeutics deployed to treat advanced prostate cancer including therapeutics that exploit androgen receptor functions. We are recruiting a post-doctoral fellow to engage in laboratory-based studies of these processes. This position will focus on delineating the molecular mechanisms contributing to the role of AR signaling in regulating gene expression and promoting tumor cell survival and proliferation with opportunities for translational studies evaluating new clinical approaches that circumvent resistance mechanisms. The research has direct relevance to the treatment of cancer patients.

Qualifications

MINUMUM QUALIFICATIONS:

• Ph.D. degree or M.D in biology; bioengineering, biochemistry; genetics; molecular biology; cell biology; immunology or related field

PREFERRED QUALIFICATIONS:

• Experience in one of the following areas is required: medicine/urology, genomics/genetics, analysis of inflammation/immune composition, biomarker characterization.
• Knowledge/exposure in biobanking, clinical trial design, and biostatistics is desired, as well as a demonstrated track record of high-quality publications.
• Expertise/skills in molecular biology techniques is desired: RT-PCR, immunohistochemistry, ELISA, cell culture, NextGen sequencing analysis, ChIPseq, drug toxicity assays.
• Candidates need to be highly-motivated, organized individuals who think independently but enjoy working as part of a dynamic, collaborative, and multidisciplinary team.
• Excellent verbal and written communication skills are essential.

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