Senior Director, Financial Planning & Analysis

Job Description

Company Overview:

Vertex is growing at a rapid pace with exciting opportunities for motivated professionals who want to contribute to our mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our Finance function plays a critical role in delivering on this mission by shaping strategy, enabling informed decision making, and providing deep business insight to support value creation across the enterprise. 

General Summary:

The Senior Director of Commercial Finance is a senior leader within the US Commercial Finance organization and serves as the primary strategic business partner to the US Commercial Vice President and Business Unit Lead. This leader will partner with the BU Lead to develop options and guide resource allocation to balance growth and profitability.  This highly visible role leads a team responsible for strategic financial management, revenue forecasting, analytics, investment management, and value creation across the business. 

Key Duties and Responsibilities:

Strategic Leadership & Business Partnership

• Serve as the finance business partner to the US Commercial Vice President and Business Unit Lead, leading strategic decision support and shaping long term commercial strategy and execution 

• Influence senior executives across Commercial, Medical, Human Resources, Global Finance, and Corporate functions to align financial plans with enterprise goals. 

• Anticipate market, competitive, and regulatory dynamics and provide actionable insights that guide commercial strategy and resource allocation. 

Financial Strategy, Planning, and Performance Management

• Lead the annual budget, long range planning process, and monthly forecasting cycles for the US Commercial BU, ensuring integration with global planning frameworks. 

• Oversee US revenue and operating expense management and drive analytical rigor and scenario planning to support portfolio optimization and launch readiness. 

• Identify value drivers and enterprise risks and develop innovative, data driven solutions to enable profitable and sustainable growth.

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Leadership, Culture, and Team Development 

• Lead and develop a high performing team with capabilities aligned to Vertex leadership behaviors and culture. 

• Build a culture of accountability, operational excellence, and continuous improvement across the Commercial Finance organization. 

• Partner with HR on workforce planning and organizational design to support the growth of the US Commercial business. 

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Cross Functional Collaboration and Enterprise Influence 

• Partner with Global Commercial Finance, Accounting, Tax, and Investor Relations to strengthen financial systems, processes, and communication. 

• Drive alignment during key business cycles ensuring readiness for launches, lifecy