Executive Director, Entrepreneur in Residence (EIR), Portfolio Strategy Team

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We recently submitted our first NDA and have funding through 2029 with >$1.4B on the balance sheet. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

Crinetics Pharmaceuticals is seeking a passionate Entrepreneur in Residence (EIR) to drive our lead clinical candidate for autosomal dominant polycystic kidney disease (ADPKD), and potentially other indications, through IND enabling studies and clinical proof-of-concept as well as pioneer new approaches to leadership of early-stage drug programs and product management in the context of a well-financed, mid-cap biotech. This role will also drive development of strategic options for the program that may include commercialization by Crinetics, partnering with larger pharma, or spin-off of a new entity. This is a unique opportunity to operate both independently and collaboratively, driving forward innovative drug development strategies and seeking creative ways to accelerate our drug development processes while maintaining regulatory and legal compliance. You will bring all the tools and passion of entrepreneurship to bear, but in the context of a well-funded and resourced environment. The ideal candidate will have a strong entrepreneurial spirit, an urgency to serve patients, a proven track record in creative drug development, and the ability to harness both internal and external resources to achieve breakthrough results. This position reports into the office of the CEO through the Chief of Staff and Head of Portfolio Strategy.

The mission of this role is to bring a potential breakthrough therapy to patients suffering with ADPKD and other potential diseases using all the tools of entrepreneurship and creative drug development in the context of a well-financed mid-cap biotech.

Essential Job Functions and Responsibilities:

Responsibilities may include, but are not limited to:

Strategic Planning & Execution:

• Develop and execute a comprehensive development plan and budget to advance our lead candidate through proof of concept, including evaluating potential new indications and opportunities.
• Operate without reliance on existing internal structures and shrewdly utilize external or internal resources, as appropriate, to rapidly, efficiently and effectively move towards regulatory approval.

Innovative Leadership:

• Act with the ownership and strategic insight of a CEO to pilot new approaches to product management and innovation, identifying blind spots, and challenging and improving existing systems.
• Support and collaborate with other Global Product Leaders (GPLs) in the Portfolio Strategy Team as a peer thought partner, enabling GPLs to blend best practices and innovations from all programs to drive operational excellence with increasing independence and creativity of product teams.

Resource Mobilization, Funding & Management

• Assemble and lead a team of experts and resources (internal or external) to identify and execute the path forward for the lead candidate for ADPKD.
• May lead efforts to secure external funding, leveraging insights from previous funding partnerships.

Entrepreneurial Culture Development:

• Serve as a thought partner to the CEO and Portfolio Strategy Team, providing entrepreneurial insights and strategies to maintain and foster a forward-thinking entrepreneurial culture within Crinetics.
• Introduce and implement novel solutions to drug development and resourcing challenges that can be replicated by other Global Product teams in advancing their programs through possibly less conventional and yet more effective methods.

Governance & Budget Management:

• Maintain alignment with internal governance at the budgetary level to ensure fiscal responsibility and strategic coherence while maintaining independent decision making that ensure the programs are moving forward efficiently.
• Adherence to applicable Crinetics polic