Principal Research Scientist II, Biologics CMC Developability

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

The Biologics CMC Developability (BCD) team is an integral part of Biologics CMC Drug Product Development group at AbbVie. The BCD team conducts biophysical, physicochemical, and forced degradation developability assessments of discovery-stage biologic drug candidates to identify liabilities and platform suitability, helping in the selection of lead candidates for pipeline advancement. We have an exciting opportunity for a motivated scientific leader to join the AbbVie Biologics CMC Developability team based in Worcester, MA.

• Champions advanced biophysics and automation workflows for Biologics CMC Developability screening
• Leads Genetic Medicine AAV characterization and Developability assessment to enable CMC Development
• Designs and implements advanced Biophysics assays for Developability screening of discovery-stage biologics including new modalities, helping select suitable candidate molecules for drug pipeline development
• Leads an Automation team (including a Senior Scientist) for high-throughput, miniaturized, data-capturing biophysical and physicochemical developability screening of Biologics
• Genetic Medicine AAV: Establishes characterization methods and Biologics CMC drug product development selection criteria for new Genetic Medicine modalities such as AAV. Assists in formulation screening and drug product platform development for new genetic medicine AAV modalities
• Leads a team of Senior Scientists for Biologics CMC developability screening of new biologic modalities including complex discovery biologic constructs
• Advances scientific expertise within function. Identifies emerging scientific trends from multiple internal and external sources and assesses relevance. Pr