Post-Doctoral Research Fellow - Chromatin Regulator and Immune Interaction in Blood Cancers, Lab of Jianping Li

Job Details

The laboratory of Dr. Jianping Li (jianpinglilab.com) at Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Thomas Jefferson University (TJU) is seeking a highly motivated postdoctoral fellow to join our team. Dr. Li’s lab focuses on the role of chromatin regulators and immune interaction in blood cancers, especially in the initiation of acute lymphoblastic leukemia and lymphoma, relapse, and chemotherapy resistance. We explore mutant chromatin regulators-driven phenotype and molecular mechanisms using cell lines, conditional mouse models, patient-derived xenografts (PDXs), and cutting-edge technologies such as CUT&RUN, ChIP-Seq, single-cell RNA-Seq, ATAC-Seq, Hi-C, proteomics, drug screening, flow cytometry and sorting, and CRISPR editing and screening (Nature Communications 2017, Cancer Discovery 2022, and Nature Chemical Biology 2024).

Job Description

Eligibility Requirements: We are looking for highly motivated and enthusiastic postdoctoral fellows with a recent PhD or MD or PhD/MD in biochemistry and molecular biology, bioinformatics, computational biology, hematology, immunology, cancer biology, or related fields. The candidate should have a strong interest in one of the following basic and translational research areas related to chromatin regulation, cancer epigenetics, stem cell biology, immune interaction, and developing targeted therapy. We are expecting you to join our energetic group, enjoy the joy of research, get excellent training, and career development to become an independent scientist. The experience of multi-omics sequencing analysis, CRISPR editing and screening, flow cytometry and sorting will be preferred. Qualified candidates should send their curriculum vitae and contact information of three professional references to Dr. Jianping Li (Jianping.li@jefferson.edu).

Institute: Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Jefferson is recognized as high performing in cancer care by U.S. News & World Report and is designated a Comprehensive Cancer Center by the National Cancer Institute (NCI) for excellence in cancer care, prevention measures, and research. The NCI-designated SKCCC at TJU is home to national thought leaders across multiple cancer research disciplines and multi-institutional collaborations, announcing the expansion and deepening of hematologic malignancy research with the Blood Cancer Center of Excellence (BCCE). Our faculty lead paradigm-shifting research into the initiation and progression of cancers, as well as resistance mechanisms and potential target therapies. Here, researchers work collaboratively across multiple departments and specialties to address some of the greatest complications in healthcare.

Work Shift

Workday Day (United States of America)

Worker Sub Type

Regular

Primary Location Address

951 Locust Street, Philadelphia, Pennsylvania, United States of America

Nationally ranked, Jefferson, which is principally located in the greater Philadelphia region, Lehigh Valley and Northeastern Pennsylvania and southern New Jersey, is reimagining health care and higher education to create unparalleled value. Jefferson is more than 65,000 people strong, dedicated to providing the highest-quality, compassionate clinical care for patients; making our communities healthier and stronger; preparing tomorrow's professional leaders for 21st-century careers; and creating new knowledge through basic/programmatic, clinical and applied research. Thomas Jefferson University, home of Sidney Kimmel Medical College, Jefferson College of Nursing, and the Kanbar College of Design, Engineering and Commerce, dates back to 1824 and today comprise