Sr. Scientist-High Throughput Receptor Pharmacology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases.  Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. 

Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro.   LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency.  Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology.  The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate.  Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

The Lead Discovery & Optimization Group leverages technology, innovation, and broad scientific knowledge to deliver comprehensive in vitro data packages to support all phases of early drug discovery at BMS. We are seeking a highly motivated and innovative scientist to drive the development and implementation of cell-based assays supporting multiple therapeutic areas. This candidate will be expected to have a breadth of cell-based assay and in vitro pharmacology expertise to support drug discovery projects from hit identification through lead optimization. Applicants should have a deep scientific and technical understanding of high-throughput screening techniques to develop complex cell-based, automated screening assays for application across drug discovery programs. The candidate should possess strong collaborative and written/verbal communication skills and a positive attitude to interact with multiple stakeholders. He/she should demonstrate personal leadership within the group, scientific leadership both at the bench and at data analysis and be adept at multi-tasking. This position is a bench scientist role and will spend the majority of time in the lab for assay design and screening.

Responsibilities:

• Collaborate closely with therapeutic area scientists to devise optimal strategies for the execution of cell-based drug discovery support within LDO.
• Ability to manage multiple projects simultaneously.
• Identify, evaluate, and implement new technologies and methods to improve upon the quality and efficiency of high-throughput receptor in vitro pharmacology HTS campaigns and SAR profiling
• Review relevant literature and leverage knowledge to solve problems in a timely fashion.
• Identify new cell technologies and reduce them to routine practice
• Analyze, interpret, and effectively present data at team meetings.

Basic Qualifications:

Bachelor’s Degree 7+ years of academic/industry experience

or

Master’s Degree 5+ years of academic/industry experience

or

PhD with 2+ years of academic / industry experience

Preferred Qualifications:

• Ph.D. in pharmacology, cell biology, or related field with in-depth experience in cell-based assay design and 2+ years of experience .
• Expertise and extensive knowledge of complex cell surface receptor pharmacology including GPCR, ion channels and transporters is required.
• Extensive experience in assay design in recombinant, primary and iPSC cellular environments for hit identification