Research Associate II / Senior Research Associate, In-Vivo Pharmacology

Lycia Therapeutics, Inc. is a biotechnology company leveraging its lysosomal targeting chimera (LYTAC) platform from Founder and Chemistry Nobel Laureate 2022, Carolyn Bertozzi, to discover and develop first-in-class therapeutics that degrade extracellular and membrane-bound proteins. Lycia’s next generation degraders harness the cell’s endogenous lysosomal trafficking and degradation machinery with the potential to degrade targets previously considered to be intractable, across a spectrum of indications. After raising $105 million in capital in 2021, Lycia is advancing an internal pipeline of novel degraders and has entered a strategic collaboration with Eli Lilly to address key unmet medical needs. In May 2024, Lycia Therapeutics completed a $106.6 million series C financing to advance its pipeline of LYTAC extracellular protein degraders to the clinic. Lycia is headquartered in South San Francisco. 
Visit https://lyciatx.com/ for more information.
The Role:Lycia Therapeutics is seeking a self-motivated, organized, and technically skilled in vivo pharmacology Research Associate II or Senior Research Associate. The successful applicant will engage in innovative research in a dynamic team environment, with a focus on developing and executing in vivo studies to support target validation and drug discovery efforts. A passion for translating basic scientific insights into generation of novel therapeutics is a must.

Responsibilities:

• As part of the in vivo pharmacology team, conduct and support in vivo studies to evaluate pharmacokinetics, pharmacodynamics, efficacy, mechanism of action, and/or tolerability of novel therapeutics based on the LYTAC platform.
• Duties will include contribution to study design, drug administration, blood collection, IVIS imaging, surgical procedures, tissue dissection/processing, and monitoring of disease models.
• Evaluate, interpret, and document scientific results and communicate findings within functional and project teams.
• Collaborate with colleagues in cross-functional project teams to support drug discovery and drug development efforts for various pipeline and platform programs.

Requirements:

• B.S/B.A or M.S. in cell biology, molecular biology, biochemistry, pharmaceutical sciences, immunology, or related field  with + 0 to 4 years of relevant experience.  Previous industry experience is preferred.
• Proficiency with animal handling procedures (e.g., husbandry, dosing via multiple routes, blood collection, organ harvests, tissue processing, etc.). Substantial experience with intravenous dosing is a plus.
• Willingness to learn new in vivo techniques.
• Ability to work independently while contributing to an integrated team.
• Must be organized and detail-oriented with meticulous record keeping.
• Flexibility to contribute to multiple studies while remaining well organized.
• Highly motivated team player with excellent written and oral communication skills.
• Proficiency in standard software (e.g., MS office and GraphPad).

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status