Head of US Commercial Operations

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.  

Role Summary: 

The Head of US Commercial Operations will bring their extensive experience to our product launches in neuromuscular disease with an initial focus on launch readiness and commercialization of our lead assets in Duchenne Muscular Dystrophy and myotonic dystrophy Type I (DM1). This individual will be a strategic and hands-on leader responsible for building and managing critical commercial infrastructure, including sales operations, analytics, forecasting, market access operations, and commercial systems. This role oversees sales operations, forecasting and analytics, incentive compensation, US market research, data management, CRM systems, field effectiveness, and commercial training. 

As part of a high performing team, this role seamlessly collaborates cross functionally to deliver a one Dyne approach, including close collaboration with field roles, Marketing, Medical Affairs, Patient Services, Global Value and Access, Finance, and IT to ensure cohesive and aligned go-to-market strategies and successful execution. As a member of the US leadership team, the ideal candidate has experience in rare disease or specialty pharmaceutical markets and thrives in an entrepreneurial, fast-paced environment.  

This role is based in Waltham, MA. 

Primary Responsibilities: 

• Serve as a key member of the US Commercial Leadership Team, developing and executing commercial operations strategy and operating plans. 

• Develops and execute the commercial operations infrastructure to support a successful rare disease product launch in DMD and DM1. 

• Lead commercial planning processes, including sales forecasting, demand planning, incentive compensation design, and territory alignment. 

• Build and oversee a high-functioning sales operations team and associated systems (CRM, data warehousing, reporting dashboards). 

• Establish data governance processes and manage third-party vendors providing data (claims, specialty pharmacy, distribution). 

• Partner cross-functionally with Marketing, Medical Affairs, Patient Services, Global Value and Access, Finance, and IT to ensure alignment of commercial operations with overall corporate goals. 

• Design and manage KPIs and reporting frameworks to track performance and inform commercial decision-making. 

• Lead field force enablement efforts, including CRM configuration, targeting, call planning, and field reporting. 

• Support the development of compliant policies and processes for commercial activities in collaboration with Legal and Compliance teams. 

• Manage operational budgets, contracts, and vendor relationships for commercial functions. 

Education, Knowledge & Skill Requirements  

The successful candidate should be a dynamic individual with proven abilities as a biopharma commercial leader. S/he will have led suc