Senior Scientist, Target ID, Immunology Cell Therapy Discovery

AstraZeneca, a global leader in biopharmaceuticals, is committed to discovering and delivering innovative therapies that transform patient outcomes. We are seeking a dedicated, hands-on Scientist or Senior Scientist to join our Immunology Cell Therapy Discovery team. The role centers on novel target identification and validation for cell therapy discovery initiatives, underpinned by an in-depth understanding of cellular and molecular immunology, pathology of inflammation and immune disorders and/or expertise in CAR-T engineering. 
 
Accountabilities  

• Expert knowledge: Demonstrate a comprehensive understanding of immunopathology at the cellular and molecular levels; multi-omics and bioinformatic data analysis; the landscape of known drug targets and therapeutics across modalities in clinical use; emerging targets with investigational therapeutics in the field; and the unmet medical needs in inflammatory and immune disorders. 

• Collaborative innovation: Partner with cross-functional teams to initiate and drive discovery efforts focused on immune disorders, enhancing AstraZeneca’s portfolio and ultimately improving patient outcomes. 

• Regulatory Compliance: Ensure adherence to all relevant laws, regulations, and company policies related to the development and delivery of medicines.  

• Research Process Development: Initiate cell therapy research—guided by curiosity, hypothesis, and data—to assess and validate novel targets, strategies, and approaches, enabling robust decision-making.  

Essential Skills/Experience  

• Advanced Degree: Masters with 5+ years of relevant experience or PhD with 0-3 years of relevant experience in Immunology, virology, innate and adaptive immune response, molecular or cell biology, bioengineering, or a related field preferred. 

• Technical Expertise: Demonstrated proficiency in T- and B-cell culture and functional assays; multicolor flow cytometry (analysis and sorting); bioinformatics; in vivo disease models; lentiviral, retroviral, or AAV vector design and engineering; CRISPR and other genome-editing technologies; nonviral gene-delivery methods; in vitro assay development; and cell-therapy research process development.  

• Scientific Expertise: Deep understanding of molecular immunology, disease biology and clinical landscape of immunological diseases.  

• Collaborative Skills: Excellent collaboration and communication capabilities, proven effectiveness working across functions and organizational levels.  

Desirable Experience  

• Publication Record / patent: Track record of peer-reviewed publications in prestigious immunological journals and/or patents. 

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. With one of the broadest and deepest Immunology pipelines in the industry, there are many oppo