Principle Scientist – Genomics (Temporary Contract)

Company Description

The work we do at Eurofins matters, and so do our employees. At Eurofins, we put a focus on your professional growth. We provide our employees the ability to break into the biopharmaceutical industry and grow from the bottom up. We have the supportive teams and tools available to invest in you while also affording you work-life balance and a competitive benefits package.

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.

If you’re looking for a rewarding career, a place to call home, apply with us today!  

Job Description

Our Principal Scientist role is a temporary contract position. The contract length for this position is ~6 months.  

The purpose of this position is to develop high-throughput cutting-edge genomic technologies to better understand disease mechanism and to accelerate the discovery of new targets and biomarkers across therapeutic areas.  The incumbent will utilize innovative genetic screening (CRISPR) and multi-omics single cell sequencing approaches (Optical pooled screening, CRISPR-Seq) to impact all stages of the pipeline from pre-clinical to clinical development.  In the position, you will collaborate closely with Oncology, Immunology, Neuroscience, Cardiometabolic disease, Pharmacology, and Chemical Biology areas throughout the Discovery, Preclinical and Translational Medicine. 

We are seeking a highly motivated scientist with expertise in cell and molecular biology, high-throughput genomic technologies, CRISPR screening and high content imaging to work directly on the client site in Cambridge, MA.  The successful candidate will be an active participant in the scientific dialogue of the group and will be able to work independently and proactively collaborate with colleagues. 

In this exciting role you will: 

• Contribute to the planning and execution of experiments to discover new drug targets in multiple therapeutic areas 

• Work with complex cellular models (primary cells, iPSC-derived cells, 2D and 3D coculture models) in addition to immortalized cell lines 

• Assist in developing, executing, analyzing and troubleshooting new cell-based assays with disease-relevant phenotypes and determine feasibility and the best approach for CRISPR screens. 

• Execute large-scale CRISPR screens in pooled and arrayed formats. 

• Use gene editing and other genomic technologies (transcriptomics, proteomics) to validate potential drug targets. 

• Communicate results and findings clearly and concisely to teams and stakeholders. 

• Maintain detailed lab notebook and records of work, help the lab manager maintain laboratory equipment used for experiments. 

• This position requires 90% of time in the lab. 

Qualifications

Education and Work Experience Requirements: 

• Ph.D. degree in cell and molecular biology or related scientific discipline or M.S. degree in cell and molecular biology or related scientific discipline with 1+ years hands-on wet lab experience in academia or industry 

Required Experience and Skills 

• Extensive hands-on experience in cell-based assay development, CRISPR-based screens 

•  Working knowledge and experience with high-content imaging assays 

•  Strong ability to troubleshoot and optimize novel methods and protocols 

•  Self-motivated and capable of prioritizing deliverables among multiple simultaneous projects 

• Excellent attention to detail and strong communication skills 

•  Ability to work independently, but also build strong relationships within highly collaborative, 

• multidisciplinary teams to effectively drive early drug discovery initiatives 

Preferred Experience and Skills: 

•  Demonstrated experience wit