Senior Scientist – Computational Biology and Bioinformatics, Kellogg Lab

Be at the forefront of the gene editing revolution and contribute to developing next generation therapies for children. Top-tier compensation and benefits, supportive and collaborative team environment with unique opportunities and exciting potential for career advancement.

As part of the Structural Biology Department at St. Jude Children’s Research Hospital, the Kellogg lab seeks a talented computational biologist who is looking to make high-impact contributions on exciting challenges at the scientific frontier of genome-editing. The Kellogg lab uses cutting edge  genetics, cryo-electron microscopy, machine-learning, and protein design to develop novel transposon-based genome-editing tools. Located on the 6th floor of the new Inspiration4 Advanced Research Center (opened in 2021), the Kellogg lab leads the forefront of research in understanding the biology of CRISPR-associated transposons (Science, 2023, Molecular Cell, 2023, Science, 2023, Nature, 2023, PNAS, 2022, Science, 2021, and more) and is well supported by the NIH, Pew Biomedical Foundation, and the Cystic Fibrosis Foundation to develop novel approaches to engineer programmable transposons for clinical gene replacement therapy. The Kellogg lab is a highly interdisciplinary scientific environment, routinely working with generously supported St. Jude research core facilities: Cryo-EM Center, the Protein Technology Center, the Single-Molecule Imaging Center, the Center for Advanced Genome Editing, and the Cell & Tissue Imaging Center. The Kellogg lab is a scientifically enriching environment with regular CRISPR supergroup discussions with Dr. Shengdar Tsai. In addition, the Kellogg lab is an active member of RosettaCommons and the Rosetta community. In this position, the candidate will be exposed to multiple, cutting edge techniques spanning cryo-electron microscopy, computational protein design, machine learning, and advanced genomics in a world class research environment aimed at advancing cures for genetic disorders.

About you

The successful candidate will be an independent learner with strong critical thinking skills and excellent communication skills. We are looking for someone with an outstanding independent track-record and stellar academic background. The ideal candidate is passionate about research and committed to developing tomorrow’s cures for children with devastating genetic disorders.

Our ideal candidate has extensive experience in one of the following (or more): bioinformatic analyses (metagenomic mining is a major plus), reconstructing evolutionary trajectories, mining transposable element databases, etc.. Scientists are expected to operate independently by leading new research directions in the Kellogg lab. The candidate will be mentored in manuscript preparation and be given opportunities for career advancement via conference attendance and oral presentation sponsorship.

Responsibilities:

• Develop new research directions under close mentorship of Dr. Kellogg.

• Stay up to date with latest CRISPR and protein engineering literature, conduct regular literature reviews in collaboration with Dr. Kellogg and other Kellogg lab members.

• Collaborate with other Kellogg lab members to design & clone large DNA libraries u