Senior Scientist, Cell Science

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.
 

• Design and execute cell line development workflows, including vector design, transfection, clone screening, and selection for stable expression.
• Perform cell culture experiments involving mammalian cells (e.g., CHO cells) under sterile, aseptic conditions.
• Develop and optimize expression systems, including promoters, selection markers, and gene amplification strategies for high-yield production.
• Screen and characterize clones for productivity, stability, growth characteristics, and product quality attributes using molecular and biochemical assays.
• Collaborate with project teams and downstream process development scientists to execute protocols, experimental plans, critical production batches, and technology transfers.
• Manage and prioritize multiple projects while supporting and coordinating with other departments to advance company objectives and develop scalable, robust culture processes.
• Write and review Standard Operating Procedures (SOPs) and technical reports for regulatory filings.
• Prepare process transfer documents and cGMP documentation to support the successful implementation of process technologies in clinical and commercial manufacturing operations.
• Collaborate with R&D and the manufacturing team in China, participating in meetings and providing technical support as needed.
• Availability to work weekend and holiday shifts, as required.
• Perform other duties as assigned.

Qualifications:

• Ph.D. in Cell Biology or a related field, with 5+ years of relevant experience in the pharmaceutical or biotechnology industry.
• Strong scientific background in recombinant protein expression, cell line development, cellular metabolism, and media optimization.
• Experience in both early- and late-stage bioreactor operations, mammalian stable cell line development, and upstream process development is preferred.
• Demonstrated expertise in advanced technologies for cell line development, with a focus on antibody production.
• Strong knowledge of FDA regulations and other global health authority requirements related to Investigational New Drug (IND) applications, particularly those concerning single stable clone selection and characterization.
• Excellent written, verbal, and interpersonal communication skills.
• Proven ability to perform effectively under pressure, meet tight deadlines, and adapt to shifting project priorities and requirements.
• Experience with high-throughput automated workstations for clone selection is highly desirable.