Senior Research Associate, Bioanalytical

About Us:

Come join a creative and collaborative team of scientists dedicated to leveraging emerging insights in RNA biology to develop novel classes of oligonucleotide therapeutics to treat human diseases and improve human health. In this role you will play a critical/vital role in DMPK Group and work closely with internal partners and external collaborators to enable identification of multiple drug candidates for human clinical studies. Please apply if you feel that you can contribute to growing our team and advance our mission.

Alltrna was founded by Flagship Pioneering, an innovation enterprise that conceives, resources, and grows first-in-category life science companies (including the now familiar drug and vaccine innovator, Moderna Therapeutics). The firm’s institutional innovation foundry, Flagship Labs, is where teams of scientific entrepreneurs systematically evolve ideas and turn previously undiscovered areas of science into real-world ventures. Flagship has created over 100 scientific ventures resulting in >$19 billion in aggregate value, 500+ issued patents, and >50 clinical trials for novel therapeutic agents. Flagship’s portfolio companies include Sana, Seres, Codiak, Rubius Therapeutics, and Indigo Agriculture.

Alltrna is seeking a collaborative and highly motivated senior research associate to join the DMPK team. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized and comfortable working on complex problems. The ideal candidate will perform lab-based activities focusing on in vitro ADME studies (e.g. metabolic stability, metabolite profiling) and in vitro biological and pharmacological assays (e.g. proteomics using mass spectrometry) to support the characterization of engineered tRNAs from discovery through to early development. You will work with many different sample types and develop sample preparation methods for various research projects.

Responsibilities:

• Support the identification and quantitation of pharmacodynamic biomarkers in various biological matrices

• Responsible for conducting routine and novel ADME-related assays for discovery and development stage compounds

• Develop, optimize and run various offline and online sample preparation and cleanup approaches
• Contribute to proteomics-based bioanalytical method development/qualification and study sample analysis
• Support general LC-MS-based assay development including instrument operation, maintenance and troubleshooting

• Participate in identifying bottlenecks for improvement or streamlining of analytical techniques as well as laboratory processes

Qualifications and Skills:

• Qualified candidate should have at least a BS in analytical chemistry/chemistry/biochemistry/pharmacology with 3-5 years of experience in the biotech/pharmaceutical industry and/or MS with 1-3 years of experience
• Experience performing and interpreting high quality quantitative in vitro ADME assays
• Working knowledge of bioanalysis of proteins and nucleic acids using at least one of the following techniques: HPLC, high-resolution mass spectrometry (HRMS), HRMS-based oligo analysis, HRMS-based protein analysis, ELISA
• Experience in manual or automated sample preparation techniques using animal matrices such as plasma, serum, lysates, and animal tissues
• Experience with peptide/protein/small molecule analysis by LC-HRMS

Core Values:

• Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.
• Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.
• Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and independently achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw insightful conclusions.
• Creativity & Innovation. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation.
• Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concise