Senior Scientist - Biochemistry

Scheduled Hours

40

Position Summary

The Galletto Lab in the Department of Biochemistry and Molecular Biophysics at the Washington University School of Medicine in Saint Louis has an immediate opening for a Senior Scientist position.

Our research strives to understand how DNA helicases promote progression of DNA replication through sites that are difficult to replicate, thereby contributing to maintenance of genomic stability. During each cell cycle, DNA replication needs to overcome multiple obstacles, such as DNA-bound proteins, DNA secondary structures, and damaged DNA. In this context, one specific focus of our research is to understand how the Pif1-family of helicases, conserved from yeast to metazoans, aid DNA replication across barriers in general, but particularly at telomeres, which are known to impede replication and whose integrity is fundamental to genome stability.

Collaborates on designing, conducting and reporting of research projects.

Job Description

Additional information on the laboratory and our research can be found at https://gallettolab.wustl.edu/.

Primary Duties & Responsibilities

• Collaborates with the PI on the design, conduct and reporting of research projects.
• Assists with grant preparation and reporting.
• Prepares and submits papers on research.
• Develops hypotheses to be tested and ways of testing it.
• Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions.
• Manages research project with other institutions and investigators.
• Performs other duties as assigned.

Working Conditions

Works in a laboratory environment with potential exposure to biological, chemical and radioactive hazards. Must be physically able to wear protective equipment and to provide standard care to research animals.

Preferred Qualifications

• Expertise in molecular biology methods, protein expression, purification and characterization.
• Expertise in one or more quantitative techniques to study macromolecular interactions and function. These include, but are not limited to, fluorescence spectroscopy, surface plasmon resonance, stopped-flow/quench flow and steady-state methods to study enzymatic activities, single molecule imaging, analytical ultracentrifugation.
• Analytical reasoning and problem-solving skills.
• Demonstrated working knowledge of standard laboratory policies, procedures and equipment.
• Ability to communicate in oral and written form with all levels of personnel and technical publications.
• Ability to work well independently or as a team member.

Required Qualifications

PhD, M.D. or equivalent terminal degree and at least 3 years of postdoctoral experience; or an equivalent combination of education and experience equaling 12 years.

Grade

R12

Salary Range

Base pay is commensurate with experience.

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required scre