PhD scholarship on Enzyme Stability Modelling and Prediction - DTU Chemical Engineering

The Bioprocess Science and Engineering (BSE) group at DTU Chemical Engineering is amongst other activities developing novel methods to measure the kinetics and stability of enzymes under industrial process conditions. 

The group is embedded in the PROSYS research center, part of DTU Chemical Engineering. Key to this scale-down approach is to ensure measurements are made at a small scale in the laboratory, saving time and money. To this end, novel equipment allows testing and the collection of experimental data. To support this goal, we are looking for a colleague who is independent, who thrives within an interdisciplinary environment, and who is highly motivated to move the area of applied biocatalysis to the next level.

We currently work with oxidative enzymes, of particular value as sustainable catalysts for the synthesis of a range of industrially valuable compounds.

This PhD project is part of the Horizon Europe Marie Skłodowska-Curie Action (MSCA) doctoral network (DN) ELEGANCE (machinE LEarning for inteGrated multi-parAmetric eNzyme and bioproCess dEsign), and it will focus on:

• Expression, characterization and application of enzymes from University of Turin and other laboratories.
• Testing enzyme in defined gas-liquid interface apparatus and other reactors to determine stability under a range of experimental conditions.
• Using the experimental data to develop a model describing the effect of conditions on stability.
• Testing the model in standard stirred tank apparatus
• Refining the model to allow predictability between different types of apparatus.
• Defining an algorithm for testing enzyme stability.

Responsibilities:

• Combine enzyme and process engineering supported by modelling as described above
• Participate in training events, workshops and secondments within MSCA doctoral network ELEGANCE
• Collaborate within the BSE research group and our local, national and international networks
• Report your research results in peer-review scientific publications and international conferences
• Disseminate your results through public engagement and social media
• Teach and supervise MSc and BSc students as well as research assistants

Qualifications:

• MSc in biotechnology, (bio)chemical engineering, or related area
• Excellent English proficiency in written and oral form
• Excellent communication and social skills for working within an interdisciplinary research team
• Strong analytical skills and ability to work independently
• Ability to convert experimental data into useful functioning models

Preferred qualifications but not mandatory:

• Interest in advanced computational methods to improve and understand enzymes

You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.

Approval and Enrolment 
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education. 

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms 
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. 

The period of employment is 3 years. The preferred starting date is 1 June 2026 (or according to mutual agreement). 

Furthermore, the PhD salary will be based on the Marie S. Curie compensation scheme conditions and according to the grant agreement. Based on seniority the candidate will receive a minimum of DKK 29.701,83 (base salary) and 1.551,00 (PhD supplement). In addition, DTU will also pay pension consisting of 18,07%. Finally, it is possible to apply for family allowance.

You can read more about career paths at DTU here.

Further information 
Further information may be obtained from John Woodley: