Direct Response Director

The Direct Response Director leads the development and implementation of multi-channel strategies that integrate direct response with journey-based approaches for Annual and Midlevel Giving at Mayo Clinic. By leveraging data-driven insights, this role creates personalized engagement experiences that deepen benefactor relationships and foster long-term philanthropic support. Reporting to the Senior Director – Annual and Midlevel Giving, the Direct Response Director collaborates across internal teams and with external partners to deliver an integrated benefactor experience aligned with organizational objectives.

Key Responsibilities:

• Strategic Program Leadership 

Lead the development and implementation of personalized, multi-channel strategies, including email, mail, and digital, that align direct response tactics with benefactor journey stages to support both short- and long-term goals across the benefactor lifecycle. Advance approaches for acquisition, retention, reactivation, and upgrading to support movement along the philanthropic pipeline and drive measurable outcomes. Ensure all efforts are aligned with strategic priorities, budget parameters, and resource allocations.

 

• Data-Driven Engagement and Performance 

Leverage segmentation, behavioral data, and performance analytics to inform and refine benefactor engagement strategies across channels. Lead testing and measurement to enhance personalization, relevance, and long-term benefactor connection to support pipeline growth and giving potential. Ensure alignment of creative and messaging to deliver timely, personalized, data-informed experiences. Share actionable insights across teams to support continuous learning and guide strategic decision-making.

 

• Cross-Team Collaboration and Integration 

Drive strategic alignment across Annual and Midlevel Giving, External Relations, Gift Planning, and other key partners to embed direct response within broader benefactor engagement efforts. Collaborate closely with the Senior Director – Annual and Midlevel Giving and coordinate with Benefactor Service, Digital Philanthropy, and Development Communications to ensure a consistent and unified benefactor experience. Lead cross-functional initiatives that support strategic priorities, strengthen integration, and enhance benefactor and philanthropic outcomes. Communicate with clarity and build trust across diverse teams, navigating ambiguity and change with confidence.

Bachelor’s degree required, with a minimum of seven years of experience in multi-channel direct response marketing, including email, mail and digital outreach. Experience within nonprofit organizations that have structured Annual and Midlevel Giving programs is strongly preferred. Proven ability to lead and implement complex, multi-channel direct response initiatives that drive long-term value. Demonstrated expertise in segmentation, behavioral insights, and performance analytics to shape personalized benefactor journeys and deepen engagement across giving levels. Advanced proficiency in data analytics and performance optimization, with the ability to translate insights into strategic decisions that enhance benefactor engagement and program outcomes. 

Exceptional verbal and written communication skills, with the ability to build trust and credibility across internal and external audiences. Highly organized, self-motivated, self-directed, and comfortable working in a dynamic, ambiguous environment. Commitment to Mayo Clinic’s mission, vision, and ethical standards, including adherence to the Donor Bill of Rights.

Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights

• Medical: Multiple plan options.
• Dental: Delta Dental or reimbursement account for flexible coverage.
• Vision: Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.