In vivo Senior Scientist (Hematology)

At AstraZeneca Oncology R&D, we are not afraid to do things differently. Our vision is redefining cancer, redefining our solutions to cancer, and restoring patients' lives.  n this role, you will join a dynamic and collaborative in vivo biology team in our state-of-the-art Biohub facility in Waltham, MA. The primary responsibilities of this position are to build and characterize in vivo animal models, conduct PKPD and efficacy studies to support our oncology R&D portfolio, with a focus on drugs targeting hematologic cancers.   

Key Responsibilities: 

• Leverage in vivo knowledge and hands-on technical skills to support our heme oncology platform capabilities and projects by: 

• Developing and working with various in vivo models of cancer including subcutaneous xenograft models, disseminated models, patient-derived xenograft (PDX) models and humanized IO models.  

• Conducting in vivo pharmacology studies (i.e., tolerability, PKPD, and efficacy) and delivering comprehensive in vivo pharmacology data packages to support both early and late-stage drug discovery programs. 

• Profiling of tissue samples to explore mechanisms of drug response and resistance using both traditional and novel approaches. 

• Demonstrate proficiency and flexibility in working with various computer programs and databases to capture all study data for broad access by project teams and stakeholders. 

• Work collaboratively across disciplines to develop and implement aggressive work plans and timelines. 

• Bring in new technologies and approaches to improve or replace existing disease model platforms to better predict clinical response. 

Minimum Qualifications:

• Bachelor’s degree with 10+ years of hands-on in vivo experience or MS/PhD in biology (immunology, hematology) pharmacology, or related field with 4+ years hands-on in vivo experience with different mouse strains and models including GEMMs, CDX and disseminated PDX mouse models, preferably in biopharma. 

• Demonstrated experience generating and working with