Sr. Principal Scientist, Oncology Translational Research, Prostate

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

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Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Translational Discovery & Development Biomarkers

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine  

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. 

Learn more at  https://www.jnj.com/innovative-medicine 

About Oncology  

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. 

Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. 

Learn more at  https://www.jnj.com/innovative-medicine 

We are seeking a highly motivated Principal or Senior Principal Scientist in Translational Research and Biomarker Strategy to lead biomarker and translational science efforts across clinical development programs in prostate cancer.  

This role will drive the design, implementation, and interpretation of biomarker strategies supporting early and late-stage clinical trials, including both registrational and exploratory studies. The successful candidate will work within a highly matrixed development environment to integrate translational science with clinical development, ensuring that biomarker data informs patient selection, pharmacodynamic assessment, and mechanisms of response and resistance.  

The candidate will partner closely with clinical development, biostatistics, diagnostics, regulatory, discovery research, and external academic collaborators to translate biological insights into actionable clinical strategies.  

This role will open the opportunity for the fitting candidate to gain experience in the novel first in class, pan-tumor potential, heterobifunctional small molecules called RIPTACs that induce tumor cell apoptosis distinct from PROTACs.   

This position requires deep scientific expertise, strong organizational and project leadership skills, and the ability to communicate complex scientific findings effectively to diverse audiences and influence across a team matrix. Details of the role include but are not limited to: 

Translational Research & Biomarker Strategy  

• Lead development and execution of integrated translational research internal and external scientific endeavors and biomarker strategies for prostate cancer drug development programs.  
• Design biomarker plans aligned with therapeutic mechanism of action and clinical development objectives pharmacodynamic (PD), target engagement (TE), response and resistance 
• Guide selectio